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- W88391318 abstract "Publisher Summary Most clinicians would accept the view that the majority of common solid tumors are systemic diseases at the time of diagnosis. This is borne out by the fact that more than 50% of the patients presenting with solid tumors that appear to be localized at the time of diagnosis eventually develop metastatic disease, irrespective of how “perfectly” the primary tumor is removed. Adjuvant systemic therapy of one form or another is, therefore, an extremely attractive concept. In theory, it represents the only way in which the outlook can be improved in the treatment of the patients presenting with neoplastic lesions that appear to be localized. Unfortunately, the current state of knowledge regarding both the behavior of malignant cells and also the drugs available to eradicate these cells from the organism is extremely limited. Because of this a number of problems are encountered when attempting to devise methods of adjuvant systemic therapy— first, the selection of patients; second, the selection of drugs; and third, the toxicity, both long and short term, associated with the use of these drugs." @default.
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- W88391318 date "1983-01-01" @default.
- W88391318 modified "2023-09-27" @default.
- W88391318 title "Adjuvant Chemotherapy for Common Solid Tumors" @default.
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- W88391318 doi "https://doi.org/10.1016/s0065-230x(08)61038-6" @default.
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