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- W88402313 abstract "This chapter discusses the transfer factor (TF) and cellular immunity to viral infection. TF is a convenient, shorthand description of the material(s) derived from circulating leukocytes of immune donors that confers a state of specific cellular immunity on nonimmune recipients. The biological properties of TF in leukocyte extracts include: (1) the initiation and prompt onset of the transferred delayed-type hypersensitivity (DTH) and the prolonged duration of this state of altered reactivity; (2) the capacity to transfer is governed by the pattern and intensity of the immunological experience of the donor and the quantity of cells used; (3) blood leukocyte preparations can transfer only DTH and cell-mediated immunity, not a primary or secondary antibody response to the same antigenic determinants so that recipients express pure DTH without the intercession of antibody; and (4) incubation of mixed cell populations of differing immunological specificities with specific antigen, purified protein derivative, results in the release of the related TF into the cell-free supernatant solution whereas TFs residing in other cells of differing specificity remains in the cell pellet. The application of the principle of TFD to the cancer patient's plight is just the beginning and any evaluation would be premature at this time." @default.
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- W88402313 date "1975-01-01" @default.
- W88402313 modified "2023-09-24" @default.
- W88402313 title "Transfer Factor and Cellular Immunity to Viral Infection" @default.
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- W88402313 doi "https://doi.org/10.1016/b978-0-12-560565-6.50016-4" @default.
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