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- W884025829 abstract "Objective To evaluate the visceral sensitivity after water-avoid stress and the effects of capsazepine and ruthenium red on visceral hypersensitivity induced by water-avoid stress. Methods 54 Wistar rats were divided into non-stress group (group Neg, n=18), normal saline group (group NS, n=12), capsazepine group (group CZP, n=12) and ruthenium red group (group RR, n=12). There were three subgroups of rates in the group Neg (intracolonic injection of NS, capsaicin and colorectal distention), and two subgroups in other three groups (intracolonic injection of capsaicin and colorectal distention). Each subgroup consisted of 6 rats. All rats were given with water avoid-stress 1 h a day for 10 days. At day-11, rats in the group Neg and group NS were then injected with solvent and rats in the group CZP and group RR were injected with capsazepine and ruthenium red, respectively. Pain induced by intracolonic injection with normal saline or capsaicin were scored in each group at 30 min after intraperitoneally injection. Abdominal rectus abdominis electromyogram (EMG) were monitored after colorectal distention (CRD) in another 6 rats in each group at 30 min after intraperitoneally injection. Results Water-avoid stress could increase the sensitivity to intracolonic injection of capsaicin. Intraperitoneal injection with capsazepine and ruthenium red could inhibit the pain behaviors induced by capsaicin. EMG counts were also increased after stress, capsazepine partially inhibited the increase in EMG counts, and ruthenium red completely inhibited the increase. Conclusion Antagonists of vanilloid receptor are effective to attenuate visceral hyperalgesia induced by water-avoid stress, and vanilloid receptor mediates process of visceral hyperalgesia." @default.
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- W884025829 date "2009-01-01" @default.
- W884025829 modified "2023-09-22" @default.
- W884025829 title "Effects of vanilloid receptor antagopnists on visceral hypersensitivity induced by water avoid stress." @default.
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