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• W8841610 abstract "In a recent issue of the Economist, the British news magazine, a question was raised: “Can goodwill, aggregated over the Internet, produce good medicine?” The author was referring to the so-called open-source model of discovery. This model is sometimes described as a distributed Internet-based collaboration. Others refer to it as a “nonproprietary peer production of information embedding goods” (Anonymous, 2004).DAVID B. NASH, MD, MBAWhatever one calls it, open-source science may have a major effect on biotechnology. I first will explore open-source discovery at its roots and then hypothesize how it might be linked to our field. Open-source approaches have been successful in another area of technology: software development. According to the Economist article, “This is a decentralized form of production in which the underlying programming instructions — or ‘source code’ — for a given piece of software are made freely available. Anyone can look at it, modify it, or improve it, provided they agree to share their modifications under the same terms.”How would this apply to biotechnology drug development?Of course, without the Internet, we never could have elucidated the human genome. It was precisely this open-source-like sharing of information and public ownership, if you will, of the science that enabled researchers to complete their work in record time. The question remains, then, could open-source discovery work elsewhere in biotechnology? I believe the answer is a qualified yes!As the Economist piece pointed out, there might be two especially critical uses of open source in drug discovery. The first would be that of nonpatentable compounds and drugs with expired patents. Here’s how it would work: Because these compounds receive little attention from researchers, there would be no way to protect and profit from any discovery made about their new uses. There may be many new and useful drugs sitting on the shelf that do not inspire further investigation. Open source would stimulate such activity.A second potential area for achieving value through open source would be products for diseases that afflict only small numbers of people, such as Parkinson’s disease. Imagine if we could extend some kind of tax benefit to companies that might work collaboratively to evaluate hundreds of molecules for their effect on narrow-band illnesses." @default.
• W8841610 created "2016-06-24" @default.
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• W8841610 date "2005-02-01" @default.
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• W8841610 title "Open-source science." @default.
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