Matches in SemOpenAlex for { <https://semopenalex.org/work/W88572054> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W88572054 abstract "Inhaled nitric oxide (iNO) causes selective pulmonary vasodilation and improves oxygenation in patients with the adult respiratory distress syndrome (ARDS). Approximately 30% of ARDS patients fail to respond to iNO. Because sepsis syndrome often accompanies a decreased response to iNO, we investigated NO responsiveness in isolated, perfused lungs from rats exposed to lipopolysaccharide (LPS). Eighteen hours after intraperitoneal injection of 0.5 mg/kg LPS, rat lungs were isolated, perfused, and preconstricted with U-46619. Ventilation with 0.4, 4, and 40 parts per million by volume NO vasodilated LPS-pretreated lungs 75, 47, and 42% less than control lungs (P < 0.01 value differs at each concentration). The diminished vasodilatory response to iNO was associated with decreased NO-stimulated guanosine 3',5'-cyclic monophosphate (cGMP) release into the perfusate. Soluble guanylate cyclase activity did not differ in lung extracts from LPS-pretreated and control rats. LPS increased pulmonary cGMP-phosphodiesterase (PDE) activity by 40%. The PDE-sensitive cGMP analogue 8-bromoguanosine 3',5'-cyclic monophosphate vasodilated lungs from LPS-pretreated rats less than lungs from control rats. In contrast, the PDE-insensitive 8-para-chlorophenylthioguanosine 3',5'-cyclic monophosphate vasodilated lungs equally from both groups. After LPS challenge, the rat pulmonary vasculature becomes hyporesponsive to iNO. Hyporesponsiveness to iNO appears partly attributable to increased pulmonary cGMP-PDE activity." @default.
- W88572054 created "2016-06-24" @default.
- W88572054 creator A5010560664 @default.
- W88572054 creator A5041302143 @default.
- W88572054 creator A5058805768 @default.
- W88572054 creator A5073059702 @default.
- W88572054 creator A5076915930 @default.
- W88572054 date "1996-12-01" @default.
- W88572054 modified "2023-09-27" @default.
- W88572054 title "Hyporesponsiveness to inhaled nitric oxide in isolated, perfused lungs from endotoxin-challenged rats" @default.
- W88572054 doi "https://doi.org/10.1152/ajplung.1996.271.6.l981" @default.
- W88572054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8997269" @default.
- W88572054 hasPublicationYear "1996" @default.
- W88572054 type Work @default.
- W88572054 sameAs 88572054 @default.
- W88572054 citedByCount "12" @default.
- W88572054 crossrefType "journal-article" @default.
- W88572054 hasAuthorship W88572054A5010560664 @default.
- W88572054 hasAuthorship W88572054A5041302143 @default.
- W88572054 hasAuthorship W88572054A5058805768 @default.
- W88572054 hasAuthorship W88572054A5073059702 @default.
- W88572054 hasAuthorship W88572054A5076915930 @default.
- W88572054 hasConcept C120770815 @default.
- W88572054 hasConcept C126322002 @default.
- W88572054 hasConcept C134018914 @default.
- W88572054 hasConcept C181199279 @default.
- W88572054 hasConcept C185592680 @default.
- W88572054 hasConcept C2776348555 @default.
- W88572054 hasConcept C2777714996 @default.
- W88572054 hasConcept C2778754761 @default.
- W88572054 hasConcept C2780994212 @default.
- W88572054 hasConcept C519581460 @default.
- W88572054 hasConcept C55493867 @default.
- W88572054 hasConcept C62826618 @default.
- W88572054 hasConcept C71924100 @default.
- W88572054 hasConcept C98274493 @default.
- W88572054 hasConceptScore W88572054C120770815 @default.
- W88572054 hasConceptScore W88572054C126322002 @default.
- W88572054 hasConceptScore W88572054C134018914 @default.
- W88572054 hasConceptScore W88572054C181199279 @default.
- W88572054 hasConceptScore W88572054C185592680 @default.
- W88572054 hasConceptScore W88572054C2776348555 @default.
- W88572054 hasConceptScore W88572054C2777714996 @default.
- W88572054 hasConceptScore W88572054C2778754761 @default.
- W88572054 hasConceptScore W88572054C2780994212 @default.
- W88572054 hasConceptScore W88572054C519581460 @default.
- W88572054 hasConceptScore W88572054C55493867 @default.
- W88572054 hasConceptScore W88572054C62826618 @default.
- W88572054 hasConceptScore W88572054C71924100 @default.
- W88572054 hasConceptScore W88572054C98274493 @default.
- W88572054 hasLocation W885720541 @default.
- W88572054 hasLocation W885720542 @default.
- W88572054 hasOpenAccess W88572054 @default.
- W88572054 hasPrimaryLocation W885720541 @default.
- W88572054 hasRelatedWork W1992290763 @default.
- W88572054 hasRelatedWork W2001610421 @default.
- W88572054 hasRelatedWork W2020863604 @default.
- W88572054 hasRelatedWork W2072803364 @default.
- W88572054 hasRelatedWork W2086715796 @default.
- W88572054 hasRelatedWork W2107858617 @default.
- W88572054 hasRelatedWork W2404186823 @default.
- W88572054 hasRelatedWork W2588617533 @default.
- W88572054 hasRelatedWork W4248317871 @default.
- W88572054 hasRelatedWork W88572054 @default.
- W88572054 isParatext "false" @default.
- W88572054 isRetracted "false" @default.
- W88572054 magId "88572054" @default.
- W88572054 workType "article" @default.