FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W885930369> ?p ?o ?g. }

• W885930369 abstract "Augmenting endothelial specific transport of the nitric oxide precursor L-arginine via cationic amino acid transporter-1 (CAT1) can prevent obesity related hypertension. We tested the hypotheses that CAT1 overexpression prevents obesity-induced hypertension by buffering the influence of the sympathetic nervous system (SNS) on the maintenance of arterial pressure and by buffering pressor responses to stress. Wild type (WT; n=13) and CAT1 overexpressing mice (CAT+; n=13) were fed a normal or a high fat diet for 20 weeks. Mice fed a high fat diet were returned to the control diet before experiments commenced. Baseline mean arterial pressure (MAP) and effects of restraint-, shaker- and almond feeding-stress and ganglionic blockade (pentolinium; 5 mg/kg; i.p.) on MAP were determined in conscious mice. Fat feeding increased body weight to a similar extent in WT and CAT+ but MAP was greater only in WT compared to appropriate controls (by 29%). The depressor response to pentolinium was 65% greater in obese WT than lean WT (P < 0.001), but was similar in obese and lean CAT+ (P = 0.65). In lean WT and CAT+, pressor responses to shaker and feeding stress, but not restraint stress, were less in the latter genotype compared to the former (P ≤ 0.001). Pressor responses to shaker and feeding stress were less in obese WT than lean WT (P ≤ 0.001), but similar in obese and lean CAT+. The increase in MAP in response to restraint stress was less in obese WT (22 ± 2%), but greater in obese CAT+ (37 ± 2%), when compared to respective lean WT (31 ± 3%) and lean CAT+ controls (27 ± 2%; P ≤ 0.02). We conclude that CAT1 overexpression prevents obesity-induced hypertension by reducing the influence of the SNS on the maintenance of arterial pressure but not by buffering pressor responses to stress." @default.
• W885930369 created "2016-06-24" @default.
• W885930369 creator A5004923126 @default.
• W885930369 creator A5012270101 @default.
• W885930369 creator A5025133583 @default.
• W885930369 creator A5046319923 @default.
• W885930369 creator A5062326097 @default.
• W885930369 date "2015-07-17" @default.
• W885930369 modified "2023-09-24" @default.
• W885930369 title "Augmented Endothelial-Specific L-Arginine Transport Blunts the Contribution of the Sympathetic Nervous System to Obesity Induced Hypertension in Mice" @default.
• W885930369 cites W1965380974 @default.
• W885930369 cites W1969634699 @default.
• W885930369 cites W1970060113 @default.
• W885930369 cites W1970643432 @default.
• W885930369 cites W1973264517 @default.
• W885930369 cites W1978680044 @default.
• W885930369 cites W1989322163 @default.
• W885930369 cites W2018377132 @default.
• W885930369 cites W2023051384 @default.
• W885930369 cites W2023387731 @default.
• W885930369 cites W2024401715 @default.
• W885930369 cites W2035612115 @default.
• W885930369 cites W2040492385 @default.
• W885930369 cites W2056306479 @default.
• W885930369 cites W2058974627 @default.
• W885930369 cites W2064265014 @default.
• W885930369 cites W2071411920 @default.
• W885930369 cites W2072206476 @default.
• W885930369 cites W2082825849 @default.
• W885930369 cites W2084998863 @default.
• W885930369 cites W2097213658 @default.
• W885930369 cites W2104422529 @default.
• W885930369 cites W2110688713 @default.
• W885930369 cites W2134733433 @default.
• W885930369 cites W2155178368 @default.
• W885930369 cites W2159417822 @default.
• W885930369 cites W2162085427 @default.
• W885930369 cites W2166161383 @default.
• W885930369 cites W2168681940 @default.
• W885930369 cites W2169180180 @default.
• W885930369 cites W2333243992 @default.
• W885930369 doi "https://doi.org/10.1371/journal.pone.0131424" @default.
• W885930369 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4505872" @default.
• W885930369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26186712" @default.
• W885930369 hasPublicationYear "2015" @default.
• W885930369 type Work @default.
• W885930369 sameAs 885930369 @default.
• W885930369 citedByCount "2" @default.
• W885930369 countsByYear W8859303692016 @default.
• W885930369 countsByYear W8859303692019 @default.
• W885930369 crossrefType "journal-article" @default.
• W885930369 hasAuthorship W885930369A5004923126 @default.
• W885930369 hasAuthorship W885930369A5012270101 @default.
• W885930369 hasAuthorship W885930369A5025133583 @default.
• W885930369 hasAuthorship W885930369A5046319923 @default.
• W885930369 hasAuthorship W885930369A5062326097 @default.
• W885930369 hasBestOaLocation W8859303691 @default.
• W885930369 hasConcept C126322002 @default.
• W885930369 hasConcept C134018914 @default.
• W885930369 hasConcept C185592680 @default.
• W885930369 hasConcept C2776452961 @default.
• W885930369 hasConcept C2776533406 @default.
• W885930369 hasConcept C2777953023 @default.
• W885930369 hasConcept C511355011 @default.
• W885930369 hasConcept C519581460 @default.
• W885930369 hasConcept C71924100 @default.
• W885930369 hasConcept C84393581 @default.
• W885930369 hasConceptScore W885930369C126322002 @default.
• W885930369 hasConceptScore W885930369C134018914 @default.
• W885930369 hasConceptScore W885930369C185592680 @default.
• W885930369 hasConceptScore W885930369C2776452961 @default.
• W885930369 hasConceptScore W885930369C2776533406 @default.
• W885930369 hasConceptScore W885930369C2777953023 @default.
• W885930369 hasConceptScore W885930369C511355011 @default.
• W885930369 hasConceptScore W885930369C519581460 @default.
• W885930369 hasConceptScore W885930369C71924100 @default.
• W885930369 hasConceptScore W885930369C84393581 @default.
• W885930369 hasLocation W8859303691 @default.
• W885930369 hasLocation W8859303692 @default.
• W885930369 hasLocation W8859303693 @default.
• W885930369 hasLocation W8859303694 @default.
• W885930369 hasOpenAccess W885930369 @default.
• W885930369 hasPrimaryLocation W8859303691 @default.
• W885930369 hasRelatedWork W1845113677 @default.
• W885930369 hasRelatedWork W1977141803 @default.
• W885930369 hasRelatedWork W1981820276 @default.
• W885930369 hasRelatedWork W1998196903 @default.
• W885930369 hasRelatedWork W2005969610 @default.
• W885930369 hasRelatedWork W2026935875 @default.
• W885930369 hasRelatedWork W2030102534 @default.
• W885930369 hasRelatedWork W2038464101 @default.
• W885930369 hasRelatedWork W2066534940 @default.
• W885930369 hasRelatedWork W2076424604 @default.
• W885930369 hasRelatedWork W2076797612 @default.
• W885930369 hasRelatedWork W2137782744 @default.
• W885930369 hasRelatedWork W2159656923 @default.
• W885930369 hasRelatedWork W2171770599 @default.
• W885930369 hasRelatedWork W2220946661 @default.
• W885930369 hasRelatedWork W2407366667 @default.
• W885930369 hasRelatedWork W2553127428 @default.

• next