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- W88639093 abstract "Throughout this monograph, all the chemical structures of platinum-based anticancer agents currently in clinical trials have been directly related to cisplatin. Thus, while leaving group (X) and carrier ligand (amine) may be varied, all the structures are described by the simple formula cis-[PtX2(amine)2]. Polynuclear platinum compounds as represented by the dinuclear and trinuclear examples of Fig. 1 comprise a further unique class of anticancer agents with distinct chemical and biologic properties discrete from their mononuclear counterparts. In June, 1998, the first drug from this class entered Phase I clinical trials. The structure of this novel trinuclear platinum agent, BBR3464, is best described as two trans-[PtC1(NH3)2] units linked by a bridging tetra-amine trans-[Pt(NH3)2H2N(CH2)6NH2)2] (Fig. 1). The compound is the first genuinely new clinical drug not based on the “classical” cisplatin structure. The structure is notable for the presence of the central coordination sphere, which contributes to DNA affinity only through electrostatic and H-bonding interactions and the overall 4+ charge." @default.
- W88639093 created "2016-06-24" @default.
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- W88639093 date "2000-01-01" @default.
- W88639093 modified "2023-09-23" @default.
- W88639093 title "Polynuclear Charged Platinum Compounds as a New Class of Anticancer Agents" @default.
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- W88639093 doi "https://doi.org/10.1007/978-1-59259-012-4_14" @default.
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