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- W88648876 abstract "We (1) have recently shown that maximal aerobic capacity ((dot V{O_{2max }})) is increased significantly in normal elderly subjects coincident with improved left ventricular diastolic function following ingestion of the centrally acting Ca2+ channel blocker, verapamil. In addition, we have shown that exercise training has resulted in increased (dot V{O_{2max }}) and faster gas exchange kinetics among the elderly (2). Hughson and Smyth (3) reported a slower increase of (dot V{O_2}) to steady state with submaximal exercise and Tesch and Kaiser (4) reported a lower (dot V{O_{2max }}) under the influence of β-adrenergic blockade in normal young subjects. The slowed responses in elderly subjects (2) and younger subjects (3) during β-adrenergic blockade may reflect impaired central or peripheral components of the (dot V{O_2}) response (5,6). Whipp et al. (7) have described the kinetics of the gas transport system by a first order model and termed the initial 20s of the (dot V{O_2}) response “cardiodynamic”. This period reflects the central or cardiac component of the (dot V{O_2}) on-transient (Phase 1). The effects of a centrally acting Ca2+ channel blocker which increased (dot V{O_{2max }}) and improved left ventricular function in the elderly (1), may also be reflected in improved kinetics in the non-steady state response to an exercise perturbation. This may result from improvement in the central component of the (dot V{O_2}) on-transient response. In order to examine this, we have analyzed the gas exchange responses in elderly men to a step increase in power output to a sub-anaerobic threshold level (40 W) before and 4 hours after ingestion of 240mg of verapamil SR." @default.
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- W88648876 date "1995-01-01" @default.
- W88648876 modified "2023-10-14" @default.
- W88648876 title "$$ dot V{O_2} $$ on-Transient Kinetics with a Centrally Acting Calcium Channel Blocker" @default.
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- W88648876 doi "https://doi.org/10.1007/978-1-4615-1933-1_38" @default.
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