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- W88658549 abstract "Background. The article aims at studying the impact of antioxidants such as mexidol, probucol and α-tocopherol on the specific efficacy of cytostatic therapy. Materials and methods. The Lewis lung carcinoma (LLC) a syngeneic tumor system obtained from a bank of tumor strains (Blokhin Cancer Research Center) was used as a model of tumor growth. LLC tumor tissues were transplanted intramuscularly in the left thigh of animals in the amount of 1 × 10 6 cells in Hanks solution (Biolot Ltd., Russia). Doxorubicine was introduced at a dose of 4 mg/kg twice in an interval of 120 hours between introductions, starting chemotherapy since the 7-th day after inoculation of LLC strain of C57Bl /6 line into mice. The antitumor effect was evaluated in terms of the index of growth of inhibition of primary tumor mass (TGI). Results. It was established that the use of antioxidants such as mexidol, probucol, α-tocopherol is safe in terms of its possible effects on tumor growth stimulation. Antitumor efficacy of antibiotics increases with concomitant introduction of daunorubicine, probucol and meksidolom, displaying a decrease in growth rate of primary tumor. Combined use of mexidol, probucol and anthracycline antibiotics increased the antimetastatic effect of antibiotics. These effects are less pronounced after α-tocopherol. Conclusions. The obtained results show the effectiveness of mexidol, probucol, α-tocopherol with doxorubicine and daunorubicine. Of all the antioxidants used it was only meksidol in combination with doxorubicine that showed the highest rates of anti-metastatic activity." @default.
- W88658549 created "2016-06-24" @default.
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- W88658549 date "2014-01-01" @default.
- W88658549 modified "2023-09-24" @default.
- W88658549 title "Оценка терапевтической эффективности совместного применения некоторых антрациклиновых антибиотиков и антиоксидантов" @default.
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