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• W88660462 abstract "Objective To investigate the role of bcl-6 gene rearrangement and bcl-6 expression in three molecular subgroups of diffuse large B-cell lymphoma(DLBCL)and its elinicopathological significance.Methods Tissue microarray including 163 newly diagnosed DLBCL was constructed.Fluorescence in situ hybridization(FISH)was performed to detect the bcl-6 gene rearrangement and immunohistochemistry(EnVision method)was used to evaluate the expression of bcl-6,Ki-67,cyclin D3,Geminin and P27Kipl proteins in DLBCL.The association with clinicopathological features was analyzed.Results One hundred and forty nine of 163 cases were further classified into three molecular subgroups:40 cases of germinal center B-cell-like(GCB)type,75 cases of activated non-germinal center B-cell-like (ABC)type,34 cases of Type 3.Of these 149 cases,FISH for bcl-6 gene rearrangement was successful in 118 cases.bcl-6 gene rearrangement was observed in 33 of 118(28.0%)cases.The bcl-6 gene rearrangement was more frequently seen in me ABC subgroup(22/62,35.5%)than in GCB(6/31,19.4%)and Type 3 subgroups(5/25,20.0%,P=0.16).The correlation of bcl-6 gene rearrangement and expression of its encoded protein was further analyzed.Most of DLBCL(26/33,78.8%)with bcl-6 gene rearrangement presented with overexpression of its encoded protein,which was higher than those without bcl-6 gene rearrangement(53/84,62.4%,P=0.088).DLBCL with bcl-6 gene rearrangement(24/33.72.7%)more frequently expressed cyclin D3,and had a higher proliferative activity than those without bcl-6 gene rearrangement(37/81,45.7%,P=0.009).Twenty-nine of 33(87.9%)cages of DLBCL with bcl-6 gene rearrangement presented with advanced stage(Ann Arbor stage Ⅲ/Ⅳ),which was hisher than those without bcl-6 gene rearrangement(65/85,76.5%,P=0.167).Univariate Cox proportional hazards regression analysis showed that bcl-6 gene rearrangement was associated with an increased relative risk (at 1.842)of death in DLBCL cases compared with those without bcl-6 gene rearrangement.Conclusion Overexpression of bcl-6 protein caused by bcl-6 gene rearrangement may play some important roles in the devdopment and/or progression of a subset of DLBCL.Key words: Lymphoma,B-cell;  Gene,bcl-6;  Gene rearrangement;  Immunophenotype:Prognosis;  Oligonueleotide array sequence analysis" @default.
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• W88660462 date "2008-06-01" @default.
• W88660462 modified "2023-10-14" @default.
• W88660462 title "[Clinicopathologic significance of bcl-6 gene rearrangement and expression in three molecular subgroups of diffuse large B-cell lymphoma]." @default.
• W88660462 doi "https://doi.org/10.3321/j.issn:0529-5807.2008.06.003" @default.
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