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- W88662477 abstract "MEDICINE Experiments were carried out in rats to study the influence of various chelate-forming compounds on the distribution of radiolead in the organism. 2: 2'-Bis-(di(carboxymethyl) -amino!-diethyldisulfide (BADDS) and 2- mercaptoethyliminodiacetic acid (MEIUA) showed the most potent activity, resulting in reduced deposition of lead. The two compounds were found superior in effect to all other substances (including ethylenediaminetetraacetic acid, diethylenetriaminepentilacetic acid, and a water-soluble derivative of dimercaptopropanol). Quantitative analysis of the results obtained indicated that BADDS occupies a specific position in the organism, which is made the subject of a detailed discussion. The activity of all chelate-forming compounds generally decreases under conditions of application at a late stage and isotopic dilution of radiolead. The decorporating effects of BADDS and MEIDA remain satisfactory even under these conditions. The therapeutic range of both substances was inferior to that of the other polyamino acids tested. (auth)" @default.
- W88662477 created "2016-06-24" @default.
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- W88662477 date "1962-01-01" @default.
- W88662477 modified "2023-09-27" @default.
- W88662477 title "THE INFLUENCE OF CHELATE-FORMING COMPOUNDS ON THE REACTIONS OF LEAD IN TH EORGANISM" @default.
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