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- W88664462 abstract "Chemoprevention is a promising approach in the use of natural or synthetic compounds to inhibit neoplastic development prior to or during the preneoplastic period. The goal of chemopreventive drug development is to identify safe and effective chemopreventive agents for clinical use (1). Agents with chemopreventive potential are tested in preclinical toxicity and pharmacokinetic studies and then moved forward to Phase I, II, and III clinical trials (1). Although many drugs may not prevent cancer completely, delaying the onset of cancer for 15–20 years may significantly increase the standard of living for an individual. For example, delaying the onset of cancer from age 55–70 or 75 provides a large window of prevention in a person’s life and therefore warrants the investigation of novel approaches into the efficacy of chemopreventive agents. Although current investigations into the targets of many chemopreventive agents spans a diverse range of cellular functions such as, inhibition of ras oncogene, epidermal growth factor receptor (EGFR), angiogenesis, and many more (2);for the purposes of this chapter, we are going to focus on agents that target components involved in cell proliferation and differentiation." @default.
- W88664462 created "2016-06-24" @default.
- W88664462 creator A5075201353 @default.
- W88664462 creator A5090645000 @default.
- W88664462 date "2003-01-01" @default.
- W88664462 modified "2023-09-23" @default.
- W88664462 title "CDK Inhibitors as Targets of Chemoprevention Agents" @default.
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