Matches in SemOpenAlex for { <https://semopenalex.org/work/W88754920> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W88754920 endingPage "474" @default.
- W88754920 startingPage "453" @default.
- W88754920 abstract "Biologics encompass a broad range of therapeutics that include proteins and other products derived from living systems. Although the multiplicity of target organs often seen with new chemical entities is generally not seen with biologics, they can produce significant adverse reactions. Examples include IL-12 and an anti-CD28 antibody that resulted in patient deaths and/or long stays in intensive care units. Mechanisms of toxicities can be categorized as pharmacological or nonpharmacological, with most, excepting hypersensitivity reactions, associated with the interaction of the agent with its planned target. Unexpected toxicities generally arise as a result of previously unknown biology. Manufacturing quality is a significant issue relative to the toxicity of biologics. The development of recombinant technology represented the single biggest advance leading to humanized products with minimal or no contaminants in comparison to products purified from animal tissues. Nevertheless, the type of manufacturing process including choice of cell type, culture medium, and purification method can result in changes to the protein. For example, a change to the closure system for erythropoietin led to an increase in aplastic anemia as a result of changing the immunogenicity characteristics of the protein. Monoclonal antibodies represent a major class of successful biologics. Toxicities associated with these agents include those associated with the binding of the complementary determining region (CDR) with the target. First dose reactions or infusion reactions are generally thought to be mediated via the Fc region of the antibody activating cytokine release, and have been observed with several antibodies. Usually, these effects (flu-like symptoms, etc.) are transient with subsequent dosing. Although biologics can have nonpharmacologic toxicities, these are less common than with small molecule drugs." @default.
- W88754920 created "2016-06-24" @default.
- W88754920 creator A5040973492 @default.
- W88754920 date "2009-09-21" @default.
- W88754920 modified "2023-10-14" @default.
- W88754920 title "Mechanisms of Adverse Drug Reactions to Biologics" @default.
- W88754920 cites W1539571840 @default.
- W88754920 cites W1705666194 @default.
- W88754920 cites W1970421475 @default.
- W88754920 cites W1974795397 @default.
- W88754920 cites W1976893749 @default.
- W88754920 cites W1979325667 @default.
- W88754920 cites W1980969801 @default.
- W88754920 cites W1990844645 @default.
- W88754920 cites W2008639498 @default.
- W88754920 cites W2011403734 @default.
- W88754920 cites W2024304683 @default.
- W88754920 cites W2029455707 @default.
- W88754920 cites W2030522563 @default.
- W88754920 cites W2041067010 @default.
- W88754920 cites W2050135580 @default.
- W88754920 cites W2050674912 @default.
- W88754920 cites W2052306755 @default.
- W88754920 cites W2057018793 @default.
- W88754920 cites W2061918270 @default.
- W88754920 cites W2069219892 @default.
- W88754920 cites W2082649398 @default.
- W88754920 cites W2084620925 @default.
- W88754920 cites W2085242627 @default.
- W88754920 cites W2086964102 @default.
- W88754920 cites W2114914602 @default.
- W88754920 cites W2134756173 @default.
- W88754920 cites W2141989396 @default.
- W88754920 cites W2143738177 @default.
- W88754920 cites W2144124503 @default.
- W88754920 cites W2151735361 @default.
- W88754920 cites W2152995522 @default.
- W88754920 cites W2154746915 @default.
- W88754920 cites W2166153412 @default.
- W88754920 cites W2188249603 @default.
- W88754920 cites W2749679400 @default.
- W88754920 doi "https://doi.org/10.1007/978-3-642-00663-0_16" @default.
- W88754920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20020272" @default.
- W88754920 hasPublicationYear "2009" @default.
- W88754920 type Work @default.
- W88754920 sameAs 88754920 @default.
- W88754920 citedByCount "34" @default.
- W88754920 countsByYear W887549202012 @default.
- W88754920 countsByYear W887549202013 @default.
- W88754920 countsByYear W887549202014 @default.
- W88754920 countsByYear W887549202015 @default.
- W88754920 countsByYear W887549202016 @default.
- W88754920 countsByYear W887549202017 @default.
- W88754920 countsByYear W887549202019 @default.
- W88754920 countsByYear W887549202020 @default.
- W88754920 countsByYear W887549202022 @default.
- W88754920 crossrefType "book-chapter" @default.
- W88754920 hasAuthorship W88754920A5040973492 @default.
- W88754920 hasConcept C159654299 @default.
- W88754920 hasConcept C197934379 @default.
- W88754920 hasConcept C203014093 @default.
- W88754920 hasConcept C2780868878 @default.
- W88754920 hasConcept C542903549 @default.
- W88754920 hasConcept C71924100 @default.
- W88754920 hasConcept C98274493 @default.
- W88754920 hasConceptScore W88754920C159654299 @default.
- W88754920 hasConceptScore W88754920C197934379 @default.
- W88754920 hasConceptScore W88754920C203014093 @default.
- W88754920 hasConceptScore W88754920C2780868878 @default.
- W88754920 hasConceptScore W88754920C542903549 @default.
- W88754920 hasConceptScore W88754920C71924100 @default.
- W88754920 hasConceptScore W88754920C98274493 @default.
- W88754920 hasLocation W887549201 @default.
- W88754920 hasLocation W887549202 @default.
- W88754920 hasOpenAccess W88754920 @default.
- W88754920 hasPrimaryLocation W887549201 @default.
- W88754920 hasRelatedWork W1560414607 @default.
- W88754920 hasRelatedWork W1591820460 @default.
- W88754920 hasRelatedWork W1606912632 @default.
- W88754920 hasRelatedWork W1899411185 @default.
- W88754920 hasRelatedWork W195682249 @default.
- W88754920 hasRelatedWork W2091371417 @default.
- W88754920 hasRelatedWork W2419379701 @default.
- W88754920 hasRelatedWork W2591016783 @default.
- W88754920 hasRelatedWork W2737158721 @default.
- W88754920 hasRelatedWork W4298901412 @default.
- W88754920 isParatext "false" @default.
- W88754920 isRetracted "false" @default.
- W88754920 magId "88754920" @default.
- W88754920 workType "book-chapter" @default.