Matches in SemOpenAlex for { <https://semopenalex.org/work/W8876833> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W8876833 endingPage "92" @default.
- W8876833 startingPage "188" @default.
- W8876833 abstract "The recent onset or deterioration of lower extremity ischemia is highly associated with intravascular thrombus. Treatment of these thrombotic occlusions is challenging. Pulse-spray catheter directed thrombolysis (PS-CDT) refers to the technique of intermittent forcefully injecting the thrombolytic agent into the thrombus to fragment it and increase the surface area available for enzymatic action. This study was designed to evaluate the efficacy and safety of PS-CDT in patients with recent onset or deterioration of lower extremity ischemia.From August 2008 to March 2009, 44 patients with acute or chronic lower extremity ischemia were recruited in this prospective study, which included 37 men and 7 women ranging from 15 to 83 years old (mean age (51.1 ± 17.4) years). PS-CDT through a multi-side-hole thrombolytic catheter by using urokinase was conducted in all patients. The progression of thrombolysis was assessed and graded by angiography. Adjunctive therapies were used to correct underlying lesions. The follow-up period was 12 months.In the 44 patients, the average total dose of urokinase for each patient was (2 120 000 ± 1 100 000) IU (median 2 000 000 IU), with a median duration of lysis of 48 hours. The rate of initial technical success was 97.7%. The rate of clinically successful lysis was 81.8%. Early (≤ 30 days) and late (from 30 days to 12 months) amputation rates were both 4.5% (2/44). The overall amputation rate was 9.1% (4/44). No mortality was recorded during thrombolysis and follow-up period (12 months). No major bleeding or allergic reaction was seen during thrombolytic therapy. 11.4% had symptoms of distal embolization. The primary patency rate for the arteries that were clinically successfully thrombolyzed as compared with those that failed to lysis was 83.3% vs. 57.1%, respectively, at 1 year.PS-CDT, combined with adjunctive therapies, is associated with good safety and efficacy in recent-onset or deterioration of lower extremity ischemia. Successful thrombolysis may be accompanied by better outcomes." @default.
- W8876833 created "2016-06-24" @default.
- W8876833 creator A5011527418 @default.
- W8876833 creator A5033482501 @default.
- W8876833 creator A5036640081 @default.
- W8876833 creator A5049821226 @default.
- W8876833 creator A5072065268 @default.
- W8876833 creator A5081676218 @default.
- W8876833 date "2012-01-01" @default.
- W8876833 modified "2023-09-25" @default.
- W8876833 title "Pulse-spray catheter directed thrombolysis in patients with recent onset or deterioration of lower extremity ischemia." @default.
- W8876833 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22340543" @default.
- W8876833 hasPublicationYear "2012" @default.
- W8876833 type Work @default.
- W8876833 sameAs 8876833 @default.
- W8876833 citedByCount "1" @default.
- W8876833 countsByYear W88768332014 @default.
- W8876833 crossrefType "journal-article" @default.
- W8876833 hasAuthorship W8876833A5011527418 @default.
- W8876833 hasAuthorship W8876833A5033482501 @default.
- W8876833 hasAuthorship W8876833A5036640081 @default.
- W8876833 hasAuthorship W8876833A5049821226 @default.
- W8876833 hasAuthorship W8876833A5072065268 @default.
- W8876833 hasAuthorship W8876833A5081676218 @default.
- W8876833 hasConcept C126322002 @default.
- W8876833 hasConcept C141071460 @default.
- W8876833 hasConcept C2776204877 @default.
- W8876833 hasConcept C2776892390 @default.
- W8876833 hasConcept C2779581417 @default.
- W8876833 hasConcept C2780643987 @default.
- W8876833 hasConcept C2781267111 @default.
- W8876833 hasConcept C2781362458 @default.
- W8876833 hasConcept C500558357 @default.
- W8876833 hasConcept C541997718 @default.
- W8876833 hasConcept C71924100 @default.
- W8876833 hasConceptScore W8876833C126322002 @default.
- W8876833 hasConceptScore W8876833C141071460 @default.
- W8876833 hasConceptScore W8876833C2776204877 @default.
- W8876833 hasConceptScore W8876833C2776892390 @default.
- W8876833 hasConceptScore W8876833C2779581417 @default.
- W8876833 hasConceptScore W8876833C2780643987 @default.
- W8876833 hasConceptScore W8876833C2781267111 @default.
- W8876833 hasConceptScore W8876833C2781362458 @default.
- W8876833 hasConceptScore W8876833C500558357 @default.
- W8876833 hasConceptScore W8876833C541997718 @default.
- W8876833 hasConceptScore W8876833C71924100 @default.
- W8876833 hasIssue "2" @default.
- W8876833 hasLocation W88768331 @default.
- W8876833 hasOpenAccess W8876833 @default.
- W8876833 hasPrimaryLocation W88768331 @default.
- W8876833 hasRelatedWork W1997551066 @default.
- W8876833 hasRelatedWork W2056441960 @default.
- W8876833 hasRelatedWork W2083043699 @default.
- W8876833 hasRelatedWork W2152227019 @default.
- W8876833 hasRelatedWork W2355205233 @default.
- W8876833 hasRelatedWork W2892344704 @default.
- W8876833 hasRelatedWork W2983239810 @default.
- W8876833 hasRelatedWork W3032589383 @default.
- W8876833 hasRelatedWork W3148217532 @default.
- W8876833 hasRelatedWork W8876833 @default.
- W8876833 hasVolume "125" @default.
- W8876833 isParatext "false" @default.
- W8876833 isRetracted "false" @default.
- W8876833 magId "8876833" @default.
- W8876833 workType "article" @default.