Matches in SemOpenAlex for { <https://semopenalex.org/work/W88768600> ?p ?o ?g. }
- W88768600 abstract "The nitrite anion has traditionally been considered an inert by-product of nitric oxide (NO) metabolism, but is now thought to be an important source of bioactive NO. Work from our department and others have implicated intrinsic vascular wall heme-proteins in a hypoxia-potentiated release of NO. The experiments presented in this thesis were designed to test the hypothesis that vascular wall myoglobin is one of the responsible proteins, and furthermore that the release of NO in relative hypoxia may be useful therapeutically in conditions such as heart failure and myocardial ischaemia. Experiments using murine aortic rings show that myoglobin is indeed an important vascular wall bioconverter of nitrite. Systemic nitrite infusions in healthy volunteers and patients with advanced heart failure show that this property of nitrite allows it to act as a specific venodilator in the latter condition; potentially overcoming some of the drawbacks of organic nitrates, such as hypotension and tolerance. Finally, studies in healthy volunteers, with and without a common variant of the aldehyde dehydrogenase enzyme, show that nitrite can protect the endothelium from ischaemia-reperfusion injury, depending upon temporal administration of the infusion and the genotype." @default.
- W88768600 created "2016-06-24" @default.
- W88768600 creator A5002621153 @default.
- W88768600 date "2011-12-01" @default.
- W88768600 modified "2023-09-27" @default.
- W88768600 title "Towards nitrite as a therapy in cardiovascular disease" @default.
- W88768600 cites W1232758273 @default.
- W88768600 cites W1523227463 @default.
- W88768600 cites W1544906050 @default.
- W88768600 cites W1574625282 @default.
- W88768600 cites W1599708797 @default.
- W88768600 cites W1662116282 @default.
- W88768600 cites W177243729 @default.
- W88768600 cites W1828441724 @default.
- W88768600 cites W1851055496 @default.
- W88768600 cites W192377712 @default.
- W88768600 cites W1947047050 @default.
- W88768600 cites W1964360120 @default.
- W88768600 cites W1965808713 @default.
- W88768600 cites W1965950958 @default.
- W88768600 cites W1967425951 @default.
- W88768600 cites W1967785796 @default.
- W88768600 cites W1969488383 @default.
- W88768600 cites W1969727059 @default.
- W88768600 cites W1971440448 @default.
- W88768600 cites W1972443719 @default.
- W88768600 cites W1973470186 @default.
- W88768600 cites W1974640233 @default.
- W88768600 cites W1974649841 @default.
- W88768600 cites W1977850625 @default.
- W88768600 cites W1978220492 @default.
- W88768600 cites W1982380290 @default.
- W88768600 cites W1982861332 @default.
- W88768600 cites W1982939197 @default.
- W88768600 cites W1985227130 @default.
- W88768600 cites W1986079719 @default.
- W88768600 cites W1987843854 @default.
- W88768600 cites W1987892382 @default.
- W88768600 cites W1989100763 @default.
- W88768600 cites W1994120155 @default.
- W88768600 cites W2000225258 @default.
- W88768600 cites W2001648357 @default.
- W88768600 cites W2002192155 @default.
- W88768600 cites W2002211489 @default.
- W88768600 cites W2003089081 @default.
- W88768600 cites W2005466083 @default.
- W88768600 cites W2007709726 @default.
- W88768600 cites W2008247353 @default.
- W88768600 cites W2008369604 @default.
- W88768600 cites W2011419550 @default.
- W88768600 cites W2013752873 @default.
- W88768600 cites W2013851960 @default.
- W88768600 cites W2014163102 @default.
- W88768600 cites W2016139728 @default.
- W88768600 cites W2016928245 @default.
- W88768600 cites W2017907872 @default.
- W88768600 cites W2018646470 @default.
- W88768600 cites W2021724833 @default.
- W88768600 cites W2021801016 @default.
- W88768600 cites W2025289525 @default.
- W88768600 cites W2028162035 @default.
- W88768600 cites W2028385511 @default.
- W88768600 cites W2028483894 @default.
- W88768600 cites W2029125680 @default.
- W88768600 cites W2030805456 @default.
- W88768600 cites W2031743773 @default.
- W88768600 cites W2033240573 @default.
- W88768600 cites W2033357754 @default.
- W88768600 cites W2033703576 @default.
- W88768600 cites W2036352285 @default.
- W88768600 cites W2037696283 @default.
- W88768600 cites W2037967237 @default.
- W88768600 cites W2038155592 @default.
- W88768600 cites W2039979152 @default.
- W88768600 cites W2040174386 @default.
- W88768600 cites W2040309436 @default.
- W88768600 cites W2041698587 @default.
- W88768600 cites W2043330101 @default.
- W88768600 cites W2043562592 @default.
- W88768600 cites W2043630278 @default.
- W88768600 cites W2046086556 @default.
- W88768600 cites W2046628294 @default.
- W88768600 cites W2047558252 @default.
- W88768600 cites W2048360028 @default.
- W88768600 cites W2049292864 @default.
- W88768600 cites W2051071984 @default.
- W88768600 cites W2052327619 @default.
- W88768600 cites W2054224182 @default.
- W88768600 cites W2056150843 @default.
- W88768600 cites W2056794597 @default.
- W88768600 cites W2056966959 @default.
- W88768600 cites W2057099146 @default.
- W88768600 cites W2057939063 @default.
- W88768600 cites W2058062846 @default.
- W88768600 cites W2058188211 @default.
- W88768600 cites W2058713290 @default.
- W88768600 cites W2060346932 @default.
- W88768600 cites W2061561528 @default.
- W88768600 cites W2061859994 @default.
- W88768600 cites W2063281374 @default.