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- W8878863 abstract "Schwann cells and the glial cells of peripheral nerves arise from the neural crest. They develop through multiple stages, including Schwann cell precursor and immature Schwann cell, before undergoing terminal differentiation. The underlying changes in gene expression are elicited by stage- or cell-specific transcription factors. Sox10 is required for Schwann cell specification, whereas Pax3, FoxD3, Sox2, and cJun help to maintain the undifferentiated and immature state. Eventually, nuclear factor-κB, Oct6, Brn2, and Krox20 act in a defined order to drive the terminal differentiation of myelinating Schwann cells." @default.
- W8878863 created "2016-06-24" @default.
- W8878863 creator A5061665380 @default.
- W8878863 date "2009-01-01" @default.
- W8878863 modified "2023-09-27" @default.
- W8878863 title "Neural Crest Diversification and Specification: Transcriptional Control of Schwann Cell Differentiation" @default.
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- W8878863 doi "https://doi.org/10.1016/b978-008045046-9.01040-8" @default.
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