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- W8883377 abstract "Undefined components in natural and synthetically-produced petroleums elicit a genotoxic response in cultured mammalian cells after exposure to light. The NUV component of the solar spectrum is the radiation responsible for photochemical transformation. The type(s) of lesion(s) induced in DNA by the photoactivation process is mimetic of FUV light-induced genotoxic lesions (bulky adduct-like) due to the similar sensitizing abilities of either insult in cells deficient in excision repair. Because of their intimate contact with the oil in the various stages associated with the production of shale oil, process waters contain significant quantities of uv-absorbing organic materials. Chemical fractionation of a process water has been achieved using an acid/base extraction scheme and reverse-phase HPLC. Resulting fractions have been assessed for photo-induced genotoxicity using a modification of the Ames/Salmonella bioassay in which NUV light is the source of activation in place of metabolic enzymes. Chemical identification of components in a photoactive peak fraction is in progress employing an additional class fractionation scheme and GC/MS methods." @default.
- W8883377 created "2016-06-24" @default.
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- W8883377 date "1982-01-01" @default.
- W8883377 modified "2023-09-27" @default.
- W8883377 title "Light activation of genotoxic components in natural and synthetic crude oils" @default.
- W8883377 hasPublicationYear "1982" @default.
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