Matches in SemOpenAlex for { <https://semopenalex.org/work/W88853318> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W88853318 endingPage "8" @default.
- W88853318 startingPage "673" @default.
- W88853318 abstract "I t has now been amply confirmed that the injection of zymosan can stimulate (6, s or depress (13, 27) host defenses against certain transplanted tumors, depending upon doses used and test circumstances. Initial experiments in our laboratory demonstrated that, if high chronic doses of zymosan were administered to mice, the animals frequently died with bacteremia of enteric origin. Indeed, these studied led to the discovery of Salmonellosis in the mouse colony (5). Based on this evidence of effect on host defense mechanisms, tests of low doses of zymosan were initiated to ascertain whether postulated defense stimulation (31) would occur which, in this case, would be active against tumors. For the past 3 years repeated experiments have been conducted in which the injection of 20 mg/kg zymosan intraperitoneally within several days of tumor implantation in 100+-day-old Swiss mice bearing Sarcoma 180 has caused 50 per cent or more regression of tumor in treated animals, as compared with 10 per cent or less regression among controls. Explorations into any possible role played by properdin in this phenomenon have been delayed by difficulties encountered in properdin assay procedures. In the meantime, information has been gathered regarding materials which can reverse zymosan activity, i.e., block the tumor regression phenomenon so that the tumors in treated animals grow and kill their hosts just like those in untreated controls. I t is the purpose of this paper to present the results of some of these studies on the reversal of the effect of zymosan on S-180 in Swiss mice and to explore further various theories which have been entertained with respect to zymosan-tumor interaction. Sarcoma 180 is recognized to be sensitive to regression; but it is this very property" @default.
- W88853318 created "2016-06-24" @default.
- W88853318 creator A5010972687 @default.
- W88853318 creator A5061604823 @default.
- W88853318 date "1959-07-01" @default.
- W88853318 modified "2023-09-23" @default.
- W88853318 title "Stimulation of host defense against experimental cancer. II. Temporal and reversal studies of the zymosan effect." @default.
- W88853318 cites W1535472005 @default.
- W88853318 cites W1550261247 @default.
- W88853318 cites W1563377063 @default.
- W88853318 cites W1642800064 @default.
- W88853318 cites W1653102362 @default.
- W88853318 cites W1967580737 @default.
- W88853318 cites W1975908451 @default.
- W88853318 cites W1982151214 @default.
- W88853318 cites W1991093014 @default.
- W88853318 cites W1995449426 @default.
- W88853318 cites W2007980618 @default.
- W88853318 cites W2022767123 @default.
- W88853318 cites W2048521429 @default.
- W88853318 cites W2078607812 @default.
- W88853318 cites W2085281873 @default.
- W88853318 cites W2104680664 @default.
- W88853318 cites W2125313754 @default.
- W88853318 cites W2202116337 @default.
- W88853318 cites W2316983588 @default.
- W88853318 cites W2320772830 @default.
- W88853318 cites W2333385408 @default.
- W88853318 cites W2347188133 @default.
- W88853318 cites W2411203414 @default.
- W88853318 cites W2414365851 @default.
- W88853318 cites W2417237413 @default.
- W88853318 cites W2967943903 @default.
- W88853318 cites W2730558950 @default.
- W88853318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/13671430" @default.
- W88853318 hasPublicationYear "1959" @default.
- W88853318 type Work @default.
- W88853318 sameAs 88853318 @default.
- W88853318 citedByCount "14" @default.
- W88853318 countsByYear W888533182016 @default.
- W88853318 crossrefType "journal-article" @default.
- W88853318 hasAuthorship W88853318A5010972687 @default.
- W88853318 hasAuthorship W88853318A5061604823 @default.
- W88853318 hasConcept C111684460 @default.
- W88853318 hasConcept C121608353 @default.
- W88853318 hasConcept C126322002 @default.
- W88853318 hasConcept C202751555 @default.
- W88853318 hasConcept C203014093 @default.
- W88853318 hasConcept C24998067 @default.
- W88853318 hasConcept C2778870864 @default.
- W88853318 hasConcept C42407357 @default.
- W88853318 hasConcept C55493867 @default.
- W88853318 hasConcept C71924100 @default.
- W88853318 hasConcept C7407320 @default.
- W88853318 hasConcept C86803240 @default.
- W88853318 hasConcept C8891405 @default.
- W88853318 hasConcept C98274493 @default.
- W88853318 hasConceptScore W88853318C111684460 @default.
- W88853318 hasConceptScore W88853318C121608353 @default.
- W88853318 hasConceptScore W88853318C126322002 @default.
- W88853318 hasConceptScore W88853318C202751555 @default.
- W88853318 hasConceptScore W88853318C203014093 @default.
- W88853318 hasConceptScore W88853318C24998067 @default.
- W88853318 hasConceptScore W88853318C2778870864 @default.
- W88853318 hasConceptScore W88853318C42407357 @default.
- W88853318 hasConceptScore W88853318C55493867 @default.
- W88853318 hasConceptScore W88853318C71924100 @default.
- W88853318 hasConceptScore W88853318C7407320 @default.
- W88853318 hasConceptScore W88853318C86803240 @default.
- W88853318 hasConceptScore W88853318C8891405 @default.
- W88853318 hasConceptScore W88853318C98274493 @default.
- W88853318 hasIssue "6, Part 1" @default.
- W88853318 hasLocation W888533181 @default.
- W88853318 hasOpenAccess W88853318 @default.
- W88853318 hasPrimaryLocation W888533181 @default.
- W88853318 hasRelatedWork W137296092 @default.
- W88853318 hasRelatedWork W1517177871 @default.
- W88853318 hasRelatedWork W1529396713 @default.
- W88853318 hasRelatedWork W1978668330 @default.
- W88853318 hasRelatedWork W1981657190 @default.
- W88853318 hasRelatedWork W2070369457 @default.
- W88853318 hasRelatedWork W2315905936 @default.
- W88853318 hasRelatedWork W2374388742 @default.
- W88853318 hasRelatedWork W2899084033 @default.
- W88853318 hasRelatedWork W94732520 @default.
- W88853318 hasVolume "19" @default.
- W88853318 isParatext "false" @default.
- W88853318 isRetracted "false" @default.
- W88853318 magId "88853318" @default.
- W88853318 workType "article" @default.