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- W888689573 abstract "-Glucosidase is an enzyme catalyzing the digestion of carbohydrates, and the uptake of carbohydrates in the intestines can be slowed down by the inhibitors of the enzyme. One of the potent inhibitors is acarbose, a drug used for the type II insulin-independent diabetes treatment, Several laboratories have made efforts into researches to find novel inhibitors. Recently, QSAR was applied to develop inhibitors of -glucosidase. In order to obtain satisfactory results from QSAR, the three dimensional-structure of the protein and its binding site should first be known. Unfortunately, even if human -glucosidase is cloned, its three-dimensional structure is still not known. Because the primary sequence of human -glucosidase shows only 24% homology with the other proteins registered in PDB, the homology modeling method cannot be used. Instead, the structure of the pseudoprotein was determined in this work. In addition, the biophores of the inhibitors were determined." @default.
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- W888689573 date "2002-01-01" @default.
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- W888689573 title "QSAR Studies of Inhibitors of ${alpha}$ -Glucosidase for Diabetes Treatment" @default.
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