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- W88875141 abstract "Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus characterized by significant eosinophilic infiltration of the esophageal mucosa. Although the exact pathogenesis of EoE remains unclear, an immunological reaction to foods and possibly to aeroallergens has been implicated based on several short-term clinical trials consisting of dietary eliminations with resultant disease remission, and observations of seasonal variability in disease severity. The immunological reaction to dietary and environmental antigens is thought to consist of a mix of IgE-mediated and non-IgE-mediated, i.e., cell-mediated, allergic reactions. Histopathologically, similar to allergic diseases in other organs, various inflammatory cells are found in increased numbers in the esophagus, including lymphocytes, mast cells, and eosinophils, the latter serving as the diagnostic hallmark for the disease. In this chapter, we summarize data demonstrating increased numbers of lymphocytes and mast cells in the esophagus of EoE patients. We also discuss evidence for the role of lymphocytes in EoE, focusing on the allergic phenotype of some of these cells. Since the role of mast cells in EoE has not been well studied, we speculate on the potential role of these cells in the pathogenesis of EoE.KeywordsEosinophilic esophagitisEsophageal mucosaFood antigensAeroallergensLymphocytesMast cellsEosinophils" @default.
- W88875141 created "2016-06-24" @default.
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- W88875141 date "2011-08-20" @default.
- W88875141 modified "2023-09-27" @default.
- W88875141 title "Role of Lymphocytes and Mast Cells in Eosinophilic Esophagitis" @default.
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- W88875141 doi "https://doi.org/10.1007/978-1-60761-515-6_5" @default.
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