Matches in SemOpenAlex for { <https://semopenalex.org/work/W888909304> ?p ?o ?g. }
- W888909304 endingPage "360" @default.
- W888909304 startingPage "350" @default.
- W888909304 abstract "Previous studies have shown dietary cholesterol can enhance learning but retard memory which may be partly due to increased cholesterol levels in hippocampus and reduced afterhyperpolarization (AHP) amplitude of hippocampal CA1 neurons. This study explored the dose-dependent effect of dietary cholesterol on synaptic plasticity of rabbit hippocampal CA1 neurons and spine morphology, the postsynaptic structures responsible for synaptic plasticity. Field potential recordings revealed a low concentration of dietary cholesterol increased long-term potentiation (LTP) expression while high concentrations produced a pronounced reduction in LTP expression. Dietary cholesterol facilitated basal synaptic transmission but did not influence presynaptic function. DiI staining showed dietary cholesterol induced alterations in dendrite spine morphology characterized by increased mushroom spine density and decreased thin spine density, two kinds of dendritic spines that may be linked to memory consolidation and learning acquisition. Dietary cholesterol also modulated the geometric measures of mushroom spines. Therefore, dietary cholesterol dose-dependently modulated both synaptic plasticity and dendrite spine morphologies of hippocampal CA1 neurons that could mediate learning and memory changes previously seen to result from feeding a cholesterol diet." @default.
- W888909304 created "2016-06-24" @default.
- W888909304 creator A5030053654 @default.
- W888909304 creator A5065591165 @default.
- W888909304 date "2015-10-01" @default.
- W888909304 modified "2023-09-29" @default.
- W888909304 title "Dietary cholesterol concentration affects synaptic plasticity and dendrite spine morphology of rabbit hippocampal neurons" @default.
- W888909304 cites W1494878660 @default.
- W888909304 cites W1498245711 @default.
- W888909304 cites W1795993777 @default.
- W888909304 cites W1798313689 @default.
- W888909304 cites W1824724965 @default.
- W888909304 cites W1840495479 @default.
- W888909304 cites W1914822635 @default.
- W888909304 cites W1965437352 @default.
- W888909304 cites W1977099164 @default.
- W888909304 cites W1980574091 @default.
- W888909304 cites W1983903556 @default.
- W888909304 cites W1984028946 @default.
- W888909304 cites W1992308207 @default.
- W888909304 cites W1992625512 @default.
- W888909304 cites W1993097076 @default.
- W888909304 cites W1993349143 @default.
- W888909304 cites W1996119383 @default.
- W888909304 cites W2003113863 @default.
- W888909304 cites W2009230396 @default.
- W888909304 cites W2010778459 @default.
- W888909304 cites W2015726495 @default.
- W888909304 cites W2016279905 @default.
- W888909304 cites W2017373417 @default.
- W888909304 cites W2030223490 @default.
- W888909304 cites W2030974529 @default.
- W888909304 cites W2033125075 @default.
- W888909304 cites W2034745336 @default.
- W888909304 cites W2039496891 @default.
- W888909304 cites W2047912165 @default.
- W888909304 cites W2060803432 @default.
- W888909304 cites W2068893416 @default.
- W888909304 cites W2070524933 @default.
- W888909304 cites W2073072782 @default.
- W888909304 cites W2073341802 @default.
- W888909304 cites W2077556948 @default.
- W888909304 cites W2078877464 @default.
- W888909304 cites W2082628782 @default.
- W888909304 cites W2083922587 @default.
- W888909304 cites W2089665913 @default.
- W888909304 cites W2090409064 @default.
- W888909304 cites W2093641478 @default.
- W888909304 cites W2105112406 @default.
- W888909304 cites W2120809634 @default.
- W888909304 cites W2120937046 @default.
- W888909304 cites W2135387950 @default.
- W888909304 cites W2136892175 @default.
- W888909304 cites W2142962566 @default.
- W888909304 cites W2143912485 @default.
- W888909304 cites W2146845170 @default.
- W888909304 cites W2168497445 @default.
- W888909304 doi "https://doi.org/10.1016/j.brainres.2015.06.049" @default.
- W888909304 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4562876" @default.
- W888909304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26188241" @default.
- W888909304 hasPublicationYear "2015" @default.
- W888909304 type Work @default.
- W888909304 sameAs 888909304 @default.
- W888909304 citedByCount "22" @default.
- W888909304 countsByYear W8889093042016 @default.
- W888909304 countsByYear W8889093042017 @default.
- W888909304 countsByYear W8889093042018 @default.
- W888909304 countsByYear W8889093042019 @default.
- W888909304 countsByYear W8889093042020 @default.
- W888909304 countsByYear W8889093042021 @default.
- W888909304 countsByYear W8889093042022 @default.
- W888909304 countsByYear W8889093042023 @default.
- W888909304 crossrefType "journal-article" @default.
- W888909304 hasAuthorship W888909304A5030053654 @default.
- W888909304 hasAuthorship W888909304A5065591165 @default.
- W888909304 hasBestOaLocation W8889093042 @default.
- W888909304 hasConcept C126322002 @default.
- W888909304 hasConcept C134018914 @default.
- W888909304 hasConcept C148762608 @default.
- W888909304 hasConcept C169760540 @default.
- W888909304 hasConcept C170493617 @default.
- W888909304 hasConcept C174884520 @default.
- W888909304 hasConcept C185592680 @default.
- W888909304 hasConcept C187541742 @default.
- W888909304 hasConcept C197341189 @default.
- W888909304 hasConcept C200170125 @default.
- W888909304 hasConcept C205383261 @default.
- W888909304 hasConcept C2524010 @default.
- W888909304 hasConcept C25274449 @default.
- W888909304 hasConcept C2778163477 @default.
- W888909304 hasConcept C2781161787 @default.
- W888909304 hasConcept C33923547 @default.
- W888909304 hasConcept C55493867 @default.
- W888909304 hasConcept C71924100 @default.
- W888909304 hasConcept C84248122 @default.
- W888909304 hasConcept C86803240 @default.
- W888909304 hasConcept C95444343 @default.
- W888909304 hasConcept C98229152 @default.