FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W88891170> ?p ?o ?g. }

• W88891170 abstract "Postoperative pain constitutes a common form of acute and persistent pain. The current approaches for postoperative pain control are inadequate and problematic. A better understanding of mechanisms for postoperative pain is necessary to improve pain management. Pain at rest is a major complaint of patients after surgery. Such ongoing pain is transmitted by increased spontaneous activity (SA) in nociceptive pathways. Using the rodent plantar incision model, guarding behavior after incision has been found as a correlate to pain at rest in patients after surgery. Similar to the time course change in pain at rest after operation, guarding behavior is the greatest immediately after plantar incision and then gradually resolves over several days. When SA in nociceptive pathways was examined previously, however, SA in both dorsal horn neurons (DHNs) and primary nociceptors was not evident immediately after plantar incision. One day after incision, great SA was present. The underlying reason for the disagreement between ongoing guarding behavior and SA in nociceptive pathways is still unknown. Here we hypothesize that incised skin has a minimal effect on the ongoing pain genesis, whereas incised deep muscle tissue produces strong ongoing pain and SA in nociceptive pathways after incision. In the first experiment, we found that skin incision induced moderate guarding on the day of incision only, whereas skin plus deep tissue incision caused guarding for 5 days. Mechanical and heat hyperalgesia were similar in both incised groups. On postoperative day (POD) 1, greater SA was present in DHNs in the skin plus deep tissue incision group than in the skin incision group. Seven days after skin plus deep tissue incision, the amount of SA in DHNs was the same as the sham control. In the second experiment, we found that on POD1 skin incision produced a similar prevalence of SA in nociceptors as sham control, whereas skin plus deep tissue incision generated a greater prevalence of SA. Seven days after skin plus deep tissue" @default.
• W88891170 created "2016-06-24" @default.
• W88891170 creator A5011446678 @default.
• W88891170 date "2018-11-29" @default.
• W88891170 modified "2023-10-11" @default.
• W88891170 title "Contribution of deep muscle tissue to ongoing pain and spontaneous activity of nociceptive pathways after plantar incision" @default.
• W88891170 cites W108060743 @default.
• W88891170 cites W1487552334 @default.
• W88891170 cites W1511198581 @default.
• W88891170 cites W1540607329 @default.
• W88891170 cites W1552250969 @default.
• W88891170 cites W1565996663 @default.
• W88891170 cites W1575571855 @default.
• W88891170 cites W1623378741 @default.
• W88891170 cites W1635224753 @default.
• W88891170 cites W1748067808 @default.
• W88891170 cites W1754799414 @default.
• W88891170 cites W1755808881 @default.
• W88891170 cites W1761965274 @default.
• W88891170 cites W1769392980 @default.
• W88891170 cites W1837386705 @default.
• W88891170 cites W1847833199 @default.
• W88891170 cites W1869902672 @default.
• W88891170 cites W1877154941 @default.
• W88891170 cites W1889938522 @default.
• W88891170 cites W1904625121 @default.
• W88891170 cites W1907866259 @default.
• W88891170 cites W1963857381 @default.
• W88891170 cites W1965779217 @default.
• W88891170 cites W1966133712 @default.
• W88891170 cites W1966917600 @default.
• W88891170 cites W1967918550 @default.
• W88891170 cites W1970227170 @default.
• W88891170 cites W1970869027 @default.
• W88891170 cites W1971261492 @default.
• W88891170 cites W1971527318 @default.
• W88891170 cites W1972858116 @default.
• W88891170 cites W1973579423 @default.
• W88891170 cites W1974054529 @default.
• W88891170 cites W1975293054 @default.
• W88891170 cites W1976829207 @default.
• W88891170 cites W1978381097 @default.
• W88891170 cites W1979979997 @default.
• W88891170 cites W1980825319 @default.
• W88891170 cites W1982173832 @default.
• W88891170 cites W1982960024 @default.
• W88891170 cites W1983902309 @default.
• W88891170 cites W1985397070 @default.
• W88891170 cites W1985527879 @default.
• W88891170 cites W1985708159 @default.
• W88891170 cites W1987211464 @default.
• W88891170 cites W1989508055 @default.
• W88891170 cites W1990832845 @default.
• W88891170 cites W1994218043 @default.
• W88891170 cites W1995277206 @default.
• W88891170 cites W1995705528 @default.
• W88891170 cites W1995763017 @default.
• W88891170 cites W1995857215 @default.
• W88891170 cites W1997237582 @default.
• W88891170 cites W1998869586 @default.
• W88891170 cites W1999047750 @default.
• W88891170 cites W1999143699 @default.
• W88891170 cites W2001011669 @default.
• W88891170 cites W2001024611 @default.
• W88891170 cites W2001128914 @default.
• W88891170 cites W2001353025 @default.
• W88891170 cites W2001833551 @default.
• W88891170 cites W2003966006 @default.
• W88891170 cites W2004623168 @default.
• W88891170 cites W2005840091 @default.
• W88891170 cites W2006119755 @default.
• W88891170 cites W2006531022 @default.
• W88891170 cites W2006618745 @default.
• W88891170 cites W2007789124 @default.
• W88891170 cites W2008442706 @default.
• W88891170 cites W2008545383 @default.
• W88891170 cites W2012702577 @default.
• W88891170 cites W2013914537 @default.
• W88891170 cites W2014874693 @default.
• W88891170 cites W2015303667 @default.
• W88891170 cites W2019727492 @default.
• W88891170 cites W2019865493 @default.
• W88891170 cites W2020296723 @default.
• W88891170 cites W2020588358 @default.
• W88891170 cites W2021220896 @default.
• W88891170 cites W2021581899 @default.
• W88891170 cites W2023601541 @default.
• W88891170 cites W2023752710 @default.
• W88891170 cites W2024003832 @default.
• W88891170 cites W2029406069 @default.
• W88891170 cites W2029649224 @default.
• W88891170 cites W2031019002 @default.
• W88891170 cites W2031764357 @default.
• W88891170 cites W2033599420 @default.
• W88891170 cites W2034194515 @default.
• W88891170 cites W2034721936 @default.
• W88891170 cites W2037956735 @default.
• W88891170 cites W2039634247 @default.
• W88891170 cites W2039812926 @default.
• W88891170 cites W2040099214 @default.

• next