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- W88901747 abstract "The laboratory study to show that tamoxifen was likely to increase the risk of endometrial cancer in women was initially rapidly confirmed by examination of an adjuvant clinical trials database. However, there was a concern raised that tamoxifen was producing high-grade endometrial cancer, but this claim turned out to be unsubstantiated. In general, the NSABP (P-1) study showed low-grade good prognosis disease with no deaths from endometrial cancer. In contrast, the laboratory finding in the early 1990s that select strains of rats were vulnerable to hepatocarcinoma following lifetime exposure to high daily doses of tamoxifen was of concern and caused labeling changes for tamoxifen. The concerns that there would be significant increases in fatal hepatocellular carcinomas were unfounded on examination of clinical trials data and subsequently ongoing monitoring of epidemiology databases." @default.
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- W88901747 date "2013-01-01" @default.
- W88901747 modified "2023-09-27" @default.
- W88901747 title "Carcinogenesis and Tamoxifen" @default.
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- W88901747 doi "https://doi.org/10.1007/978-3-0348-0664-0_6" @default.
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