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- W889276599 abstract "目的探讨核转录因子-κB（nuclear factor kappaB，NF-κB）及细胞外信号调节激酶（extracegularsignal—reglulatedkinase，ERK）mRNA在CCl4致实验性肝纤维化大鼠肝组织中的表达及姜黄素（curcumin，CUR）对它们的影响。方法建立CCl4致大鼠实验性肝纤维化的模型，用免疫组化法比较正常组、模型组及CUR组的α平滑肌肌动蛋白（α-SMA）的表达，用RT-PCR法比较各组肝组织NF-κB及ERK-1mRNA的表达。结果模型组中，ERK-1及NF-κBmRNA的表达均增高，而CUR组α平滑肌肌动蛋白则较模型组低，NF-κB及ERK-1mRNA的表达也降低。结论CUR可能通过抑制α-SMA的表达，减弱NF-κB诱导的肝星状细胞的活化及抑制ERK-1促肝星状细胞的增殖，从而产生抗四氯化碳诱导的大鼠肝纤维化的作用。" @default.
- W889276599 created "2016-06-24" @default.
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- W889276599 date "2009-01-01" @default.
- W889276599 modified "2023-10-18" @default.
- W889276599 title "姜黄素对实验性肝纤维化大鼠肝组织中NF—κB及ERK-1 mRNA表达的影响" @default.
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