Matches in SemOpenAlex for { <https://semopenalex.org/work/W8894008> ?p ?o ?g. }
- W8894008 endingPage "157" @default.
- W8894008 startingPage "150" @default.
- W8894008 abstract "Viruses are associated with the development of periodontal disease, particularly during periods of suppressed cellular immunity. For this reason, we evaluated the hypothesis that viral components regulate the actions of histamine, an important mediator of immune responses. We assessed the effect of Poly (I:C) on histamine-mediated intracellular calcium mobilization in human gingival fibroblasts. Our results show that histamine induces an increase in intracellular calcium concentrations in a dose-dependent manner. This response was blocked when cells were incubated in the presence of Poly (I:C). In addition, phorbol esters, a diacylglycerol analog, mimics the inhibitory actions of Poly (I:C) in response to histamine. The effect of Poly (I:C) was reversed by Stuarosporine (1 μM), GÖ6983 (7 μM), Bisindolylmaleimide (1 μM) [a protein inhibitor (PKC)], and SB 203580 (3 μM) (a p38-MAPK inhibitor). These findings suggest that Poly (I:C) regulates histamine-induced calcium mobilization through activation of PKC and p38." @default.
- W8894008 created "2016-06-24" @default.
- W8894008 creator A5005569305 @default.
- W8894008 creator A5089616591 @default.
- W8894008 date "2012-01-01" @default.
- W8894008 modified "2023-09-30" @default.
- W8894008 title "Toll-like receptor 3 activation promotes desensitization of histamine response in human gingival fibroblasts" @default.
- W8894008 cites W1544652523 @default.
- W8894008 cites W1911709556 @default.
- W8894008 cites W1934712179 @default.
- W8894008 cites W1964053725 @default.
- W8894008 cites W1964634342 @default.
- W8894008 cites W1966059975 @default.
- W8894008 cites W1967756818 @default.
- W8894008 cites W1970037640 @default.
- W8894008 cites W1972285445 @default.
- W8894008 cites W1982367228 @default.
- W8894008 cites W1992439632 @default.
- W8894008 cites W1998211335 @default.
- W8894008 cites W2004027006 @default.
- W8894008 cites W2005020852 @default.
- W8894008 cites W2005571008 @default.
- W8894008 cites W2025836263 @default.
- W8894008 cites W2027250920 @default.
- W8894008 cites W2042316145 @default.
- W8894008 cites W2059463894 @default.
- W8894008 cites W2067359484 @default.
- W8894008 cites W2069445034 @default.
- W8894008 cites W2081526691 @default.
- W8894008 cites W2082082455 @default.
- W8894008 cites W2090020016 @default.
- W8894008 cites W2091818728 @default.
- W8894008 cites W2107182434 @default.
- W8894008 cites W2114637517 @default.
- W8894008 cites W2118435863 @default.
- W8894008 cites W2122414869 @default.
- W8894008 cites W2122550126 @default.
- W8894008 cites W2129938274 @default.
- W8894008 cites W2134846627 @default.
- W8894008 cites W2137231634 @default.
- W8894008 cites W2139263536 @default.
- W8894008 cites W2141260882 @default.
- W8894008 cites W2147724351 @default.
- W8894008 cites W2171260427 @default.
- W8894008 doi "https://doi.org/10.1016/j.cellimm.2011.12.005" @default.
- W8894008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22285102" @default.
- W8894008 hasPublicationYear "2012" @default.
- W8894008 type Work @default.
- W8894008 sameAs 8894008 @default.
- W8894008 citedByCount "4" @default.
- W8894008 countsByYear W88940082012 @default.
- W8894008 countsByYear W88940082016 @default.
- W8894008 countsByYear W88940082021 @default.
- W8894008 countsByYear W88940082022 @default.
- W8894008 crossrefType "journal-article" @default.
- W8894008 hasAuthorship W8894008A5005569305 @default.
- W8894008 hasAuthorship W8894008A5089616591 @default.
- W8894008 hasConcept C10335311 @default.
- W8894008 hasConcept C1122143 @default.
- W8894008 hasConcept C126322002 @default.
- W8894008 hasConcept C134018914 @default.
- W8894008 hasConcept C170493617 @default.
- W8894008 hasConcept C181080969 @default.
- W8894008 hasConcept C185592680 @default.
- W8894008 hasConcept C195794163 @default.
- W8894008 hasConcept C203014093 @default.
- W8894008 hasConcept C2107291 @default.
- W8894008 hasConcept C2776885963 @default.
- W8894008 hasConcept C2777314051 @default.
- W8894008 hasConcept C36020004 @default.
- W8894008 hasConcept C51551487 @default.
- W8894008 hasConcept C519063684 @default.
- W8894008 hasConcept C55493867 @default.
- W8894008 hasConcept C57074206 @default.
- W8894008 hasConcept C62478195 @default.
- W8894008 hasConcept C71924100 @default.
- W8894008 hasConcept C79879829 @default.
- W8894008 hasConcept C86803240 @default.
- W8894008 hasConcept C95444343 @default.
- W8894008 hasConceptScore W8894008C10335311 @default.
- W8894008 hasConceptScore W8894008C1122143 @default.
- W8894008 hasConceptScore W8894008C126322002 @default.
- W8894008 hasConceptScore W8894008C134018914 @default.
- W8894008 hasConceptScore W8894008C170493617 @default.
- W8894008 hasConceptScore W8894008C181080969 @default.
- W8894008 hasConceptScore W8894008C185592680 @default.
- W8894008 hasConceptScore W8894008C195794163 @default.
- W8894008 hasConceptScore W8894008C203014093 @default.
- W8894008 hasConceptScore W8894008C2107291 @default.
- W8894008 hasConceptScore W8894008C2776885963 @default.
- W8894008 hasConceptScore W8894008C2777314051 @default.
- W8894008 hasConceptScore W8894008C36020004 @default.
- W8894008 hasConceptScore W8894008C51551487 @default.
- W8894008 hasConceptScore W8894008C519063684 @default.
- W8894008 hasConceptScore W8894008C55493867 @default.
- W8894008 hasConceptScore W8894008C57074206 @default.
- W8894008 hasConceptScore W8894008C62478195 @default.
- W8894008 hasConceptScore W8894008C71924100 @default.