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- W88946355 abstract "Varicella-zoster virus can to modulate the expression of class I and class II major histocompatibility (MHC) molecules. MHC class I expression is downregulated in VZV-infected T cells as well as in fibroblasts. VZV-infected cells do not respond to exposure to interferon-gamma (IFN-gamma) by upregulation of MHC class II expression. However, MHC class II expression is induced when cells are treated with IFN-gamma before VZV infection. These effects on MHC class I and class II expression can be expected to interfere transiently with adaptive immune responses of the host, mediated by CD4 and CD8 T cells, ensuring that the virus has sufficient opportunity for transmission to susceptible contracts." @default.
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- W88946355 date "2001-01-01" @default.
- W88946355 modified "2023-09-23" @default.
- W88946355 title "Immune evasion mechanisms of varicella-zoster virus" @default.
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- W88946355 doi "https://doi.org/10.1007/978-3-7091-6259-0_11" @default.
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