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- W88946711 abstract "The marine sponge metabolite ilimaquinone has a wide range of biological activities, including vesiculation of the Golgi apparatus and interference with intracellular protein trafficking. Some of these activities may arise from ilimaquinone's influence on the activated methyl cycle. To visualize the morphological effects of ilimaquinone on the Golgi apparatus, NRK (normal rat kidney) cells were labeled with fluorescent wheat germ agglutinin and treated with ilimaquinone in the presence and absence of the methylating agent S-adenosylmethionine (SAMe). While ilimaquinone alone fragments the Golgi apparatus, the organelle remains intact when SAMe is included in the incubation mixture. This observation supports ilimaquinone's interaction with methylation enzymes as the cause of Golgi vesiculation. The examination of a fluorescently labeled ilimaquinone analogue in NRK cells suggests that the cellular interactions of ilimaquinone are not localized to the Golgi apparatus." @default.
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- W88946711 date "2001-01-01" @default.
- W88946711 modified "2023-09-27" @default.
- W88946711 title "S -adenosylmethionine reverses ilimaquinone's vesiculation of the Golgi apparatus" @default.
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- W88946711 doi "https://doi.org/10.1016/s0960-894x(00)00617-x" @default.
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