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- W88963204 abstract "A number of physiological processes, such as nerve activity, epithelial transport and apoptosis, involve changes in cell volume. The KCa1.1 - (Slo, BK, MaxiK) - related potassium channels Slo2.1 (Slick) and Slo2.2 (Slack) are activated by intracellular Na+ and Cl– and inhibited by intracellular ATP. Both channels are widely expressed in different tissues, including dura mater, middle cerebral artery and basilar artery confirmed by RT-PCR. In this study we examined the possible regulation of Slo2.1 and Slo2.2 by small, fast changes in cell volume in Xenopus oocytes after co-expression with aquaporins (AQP1) to ensure high water permeability. Our results show that Slo2.1 is dramatically stimulated (to 196% of control) by cell swelling of approximately 5%, and inhibited (to 44% of control) by a similar decrease in cell volume. In contrast, changes in cell volume did not affect the Slo2.2 channels. Therefore it is suggested that cell volume is a significant regulatory parameter for Slo2.1 and that these channels may play an important role in regulating intracellular potassium concentration during changes in cell volume." @default.
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- W88963204 date "2008-03-01" @default.
- W88963204 modified "2023-09-23" @default.
- W88963204 title "Slo2.1 (Slick), but not Slo2.2 (Slack), is regulated by changes in cell volume" @default.
- W88963204 doi "https://doi.org/10.1096/fasebj.22.1_supplement.933.14" @default.
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