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- W88970055 abstract "Publisher Summary This chapter discusses a common frame of perception or universe of discourse in developmental biology. Development is a series of interlocking processes involving molecular interactions revealed in the communication between nucleus and cytoplasm, in induction, and in the coordination of cell movements. The most fruitful new generalizations of the immediate future are likely to emerge from the frame of perception provided by molecular genetics: the concept of levels of control and their interactions; and the concept of regulation. The importance of agitating existing information, leading to changing concepts, is exemplified by the advances arising out of a reconsideration of the relations between DNA replication and transcription. The chapter tries to carry the generalization a step further, and to examine its implications. The fact that many tissues for example, lens and muscle, undergo rapid cell division prior to “terminal” differentiation raised the question whether new transcription may depend upon an immediately preceding replication. However, it was not until studies of the mechanism of transformation of cells by tumor viruses revealed a requirement for cellular DNA synthesis that the importance of reexamining these relations was brought home." @default.
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- W88970055 date "1968-01-01" @default.
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- W88970055 title "Levels of Control: A Useful Frame of Perception" @default.
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- W88970055 doi "https://doi.org/10.1016/s0070-2153(08)60348-8" @default.
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