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- W8898774 abstract "Abstract Neurons in the mammalian central nervous system (CNS) undergo a developmental loss in their ability to grow axons as they mature, which is a critical contributing factor to the failure of nerve regeneration and repair after injury. This growth failure can be attributed, at least in part, to the induction of molecular programs preventing cellular overgrowth and termination of axonal growth on maturation. Key intracellular signals and transcription factors, including Bcl-2, cyclic adenine monophospate (cAMP), mammalian target of rapamycin (mTOR), and Kruppel-like transcription factors (KLFs), have been identified as playing central roles in this process. This chapter will provide an overview introducing the functions of these intracellular signals in their regulation of CNS axon regeneration." @default.
- W8898774 created "2016-06-24" @default.
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- W8898774 date "2015-01-01" @default.
- W8898774 modified "2023-10-16" @default.
- W8898774 title "The Intrinsic Determinants of Axon Regeneration in the Central Nervous System" @default.
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- W8898774 doi "https://doi.org/10.1016/b978-0-12-801732-6.00012-4" @default.
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