Matches in SemOpenAlex for { <https://semopenalex.org/work/W890050685> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W890050685 endingPage "756" @default.
- W890050685 startingPage "752" @default.
- W890050685 abstract "目的：通过改变食物硬度造成大鼠生长早期颞下颌关节软骨的负荷改变,检测髁突软骨中血管内皮生长因子（vascular endothelial growth factor,VEGF）、聚集蛋白聚糖酶-1（aggrecanase-1）和金属蛋白酶抑制剂因子-3（tissue inhibitor of metallopro-teinase,TIMP-3）mRNA的表达变化,探讨其在髁突软骨发育中的意义。方法：40只21 d龄SD雌性大鼠同时哺乳与喂食粉末样食物,第28天断奶,随机分为2组：对照组仍喂食粉末样食物,实验组改喂同种成分的硬块状食物,食物改变后,在24、48h、7 d,14d每组各处死5只大鼠。解剖切取双侧髁突软骨,半定量RT-PCR检测其中VEGF、aggrecanase-1和TIMP-3 mRNA表达。结果：在硬食物组7 d和14 d髁突软骨中VEGF mRNA的表达均高于软食物组（P〈0.05）;在硬食物组7 d髁突软骨中aggrecanase-1 mRNA的表达高于软食物组（P〈0.05）;在软食物组24 h髁突软骨中TIMP-3 mRNA的表达高于硬食物组（P〈0.05）,其他时间点上无明显差异。结论：在改变食物负荷后aggrecanase-1和TIMP-3 mRNA在大鼠生长发育早期的髁突软骨中的表达变化是一种在生理范围内的暂时、适应性改变;而VEGF mRNA的表达变化可能参与了髁突软骨的发育并且与食物负荷的持续性成正相关,但晚于aggrecanase-1和TIMP-3 mRNA表达变化。" @default.
- W890050685 created "2016-06-24" @default.
- W890050685 creator A5024395067 @default.
- W890050685 creator A5043198698 @default.
- W890050685 creator A5088020822 @default.
- W890050685 creator A5088352573 @default.
- W890050685 date "2011-01-01" @default.
- W890050685 modified "2023-09-24" @default.
- W890050685 title "改变食物硬度对大鼠生长早期髁突软骨中VEGF、aggrecanase-1和TIMP-3 mRNA表达的影响" @default.
- W890050685 hasPublicationYear "2011" @default.
- W890050685 type Work @default.
- W890050685 sameAs 890050685 @default.
- W890050685 citedByCount "0" @default.
- W890050685 crossrefType "journal-article" @default.
- W890050685 hasAuthorship W890050685A5024395067 @default.
- W890050685 hasAuthorship W890050685A5043198698 @default.
- W890050685 hasAuthorship W890050685A5088020822 @default.
- W890050685 hasAuthorship W890050685A5088352573 @default.
- W890050685 hasConcept C104317684 @default.
- W890050685 hasConcept C105580179 @default.
- W890050685 hasConcept C142724271 @default.
- W890050685 hasConcept C167734588 @default.
- W890050685 hasConcept C185592680 @default.
- W890050685 hasConcept C204787440 @default.
- W890050685 hasConcept C2776157581 @default.
- W890050685 hasConcept C2776164576 @default.
- W890050685 hasConcept C3020332539 @default.
- W890050685 hasConcept C502942594 @default.
- W890050685 hasConcept C55493867 @default.
- W890050685 hasConcept C70721500 @default.
- W890050685 hasConcept C71924100 @default.
- W890050685 hasConcept C86803240 @default.
- W890050685 hasConcept C95444343 @default.
- W890050685 hasConceptScore W890050685C104317684 @default.
- W890050685 hasConceptScore W890050685C105580179 @default.
- W890050685 hasConceptScore W890050685C142724271 @default.
- W890050685 hasConceptScore W890050685C167734588 @default.
- W890050685 hasConceptScore W890050685C185592680 @default.
- W890050685 hasConceptScore W890050685C204787440 @default.
- W890050685 hasConceptScore W890050685C2776157581 @default.
- W890050685 hasConceptScore W890050685C2776164576 @default.
- W890050685 hasConceptScore W890050685C3020332539 @default.
- W890050685 hasConceptScore W890050685C502942594 @default.
- W890050685 hasConceptScore W890050685C55493867 @default.
- W890050685 hasConceptScore W890050685C70721500 @default.
- W890050685 hasConceptScore W890050685C71924100 @default.
- W890050685 hasConceptScore W890050685C86803240 @default.
- W890050685 hasConceptScore W890050685C95444343 @default.
- W890050685 hasIssue "6" @default.
- W890050685 hasLocation W8900506851 @default.
- W890050685 hasOpenAccess W890050685 @default.
- W890050685 hasPrimaryLocation W8900506851 @default.
- W890050685 hasVolume "27" @default.
- W890050685 isParatext "false" @default.
- W890050685 isRetracted "false" @default.
- W890050685 magId "890050685" @default.
- W890050685 workType "article" @default.