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- W89039392 abstract "Distribution of atherosclerosis suggests that the local environment of susceptible sites harbors the factors for atherogenesis. Geometry of brachpoints, ostia, and curvatures, where atheromas usually develop, implies a role for disturbed flow. It is not clear what specific alterations are caused by disturbed shear-stress in the susceptible sites that are pro-atherogenic. We hypothesized that disturbed flow leads to increase in expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in endothelial cells, since the promoter region of its gene was shown to contain two shear-stress response elements (Aoyama, Biochem. J. 339:177, 1999). Endothelial cells in artificial capillary tubes were subjected to atheroprone, oscillatory flow using a computer controlled pump for 24 h. Atherogenic flow pulse simulating carotid bifurcation shear-stress pattern (Dai, PNAS 101:14871, 2004) was generated by the DasyLab software and transmitted to the pump using the analog output of an Iotech data acquisition and control card. Disturbed flow resulted in significant upregulation of LOX-1 protein expression compared with atheroprotective flow as determined by Western blot analysis. Increased expression of LOX-1 under disturbed flow might lead to increased uptake of oxidized LDL and thus facilitate atherogenesis." @default.
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- W89039392 date "2006-03-01" @default.
- W89039392 modified "2023-09-23" @default.
- W89039392 title "Atheroprone shear‐stress upregulates LOX‐1 expression in endothelial cells" @default.
- W89039392 doi "https://doi.org/10.1096/fasebj.20.4.a205-c" @default.
- W89039392 hasPublicationYear "2006" @default.
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