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• W89062216 abstract "No AccessJournal of Urology1 Sep 1975Nitrofurantoin, Sulfamethizole and Cephalexin Urinary Concentration in Unequally Functioning Pyelonephritic Kidneys J.W. Sullivan, A.J. Bueschen, and J.U. Schlegel J.W. SullivanJ.W. Sullivan Research Trainee, United States Public Health Service Training Grant 5 TO1 AM 05607-05. More articles by this author , A.J. BueschenA.J. Bueschen Research Trainee, United States Public Health Service Training Grant 5 TO1 AM 05607-04. Current address: Division of Urology, Department of Surgery, University of Alabama Medical Center, Birmingham, Alabama 35294. More articles by this author , and J.U. SchlegelJ.U. Schlegel More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)67025-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Nitrofurantoin, sulfamethizole and cephalexin peak urinary drag concentrations were studied in patients and non-human primates with unequally functioning pyelonephritie kidneys. The peak urinary drug concentration of the poorly functioning kidney in comparison to the better kidney was greater than its percentage relative blood flow or creatinine clearance but variable in its relationship to creatinine concentration, osmolality and sodium concentration. Although for each unit of creatinine clearance the poorly functioning kidney had a higher peak urinary drug concentration than the better functioning kidney, for each kidney the peak urinary drug concentration seemed to be directly proportional to the creatinine clearance, the drug dosage and the renal mechanisms of drug excretion. Nitrofurantoin in the usual recommended dosage did not reach minimal inhibitory urinary drug concentration below a unilateral creatinine clearance of 20ml. per minute. Whereas, sulfamethizole and cephalexin reached peak urinary drug concentrations greater than the minimal inhibitory concentration at the lowest studied unilateral creatinine clearances of 4 and 11ml. per minute, respectively. © 1975 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 114Issue 3September 1975Page: 343-347 Advertisement Copyright & Permissions© 1975 by The American Urological Association Education and Research, Inc.MetricsAuthor Information J.W. Sullivan Research Trainee, United States Public Health Service Training Grant 5 TO1 AM 05607-05. More articles by this author A.J. Bueschen Research Trainee, United States Public Health Service Training Grant 5 TO1 AM 05607-04. Current address: Division of Urology, Department of Surgery, University of Alabama Medical Center, Birmingham, Alabama 35294. More articles by this author J.U. Schlegel More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W89062216 title "Nitrofurantoin, Sulfamethizole and Cephalexin Urinary Concentration in Unequally Functioning Pyelonephritic Kidneys" @default.
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• W89062216 doi "https://doi.org/10.1016/s0022-5347(17)67025-3" @default.
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