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- W89066265 abstract "Abstract Dendritic cells (DC) play critical roles in Ag presentation and induction of immunity or tolerance. In previous our study, treatment of agonistic anti-CD40 mAb at that time of oral OVA did not abolish the oral tolerance induction whereas injection of α-galactosylceramide (αGC) blocked the oral tolerance. We demonstrate that treatment of αGC but not anti-CD40 mAb resulted in the full maturation of DC in lamina propria of small intestine (SI-LP) at early time window. This phenomenon caused by activated NKT cells which reside in SI-LP. DC in SI-LP (sLP-DC) from αGC-treated mice exhibited a stronger stimulator against allogeneic T cells than those cells from anti-CD40 mAb-treated mice. Ag presentation capability was also increased in sLP-DC by αGC. Importantly, maturated sLP-DC by αGC induced to differentiate of naïve CD4+ T cells into Th1- and Th2 cells toward intestinal OVA. In contrast, sLP-DC by anti-CD40 mAb treatment failed to generate Th differentiation but were involved in the generation of more numbers of Foxp3+ CD4+ T cells than those from αGC-treated group. On the other hand, the fact that recognition of intestinal Ag of naïve CD4+ T cells occurs in MLN, indicating MLN are privileged in triggering the interactions of sLP-DC and CD4+ T cells. Taken together, systemic treatment of αGC resulted in maturation of sLP-DC by NKT cells in the SI-LP and licensed DC educate CD4+ T cells in MLN, which can abrogate oral tolerance." @default.
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- W89066265 date "2007-04-01" @default.
- W89066265 modified "2023-10-18" @default.
- W89066265 title "Activation of NKT cells by a-Galactosylceramide treatment licenses lamina propria dendritic cells to abrogate the oral tolerance (42.10)" @default.
- W89066265 doi "https://doi.org/10.4049/jimmunol.178.supp.42.10" @default.
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