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- W89069999 endingPage "201" @default.
- W89069999 startingPage "175" @default.
- W89069999 abstract "Secretory elements in the airways have a parasympathetic (cholinergic) supply, and activation of cholinergic nerves or administration of cholinomimetic drugs induces marked increases in secretion. In health, secreted high molecular weight glycoproteins (mucins) comprise a small proportion (~ 1%) of the thin layer of aqueous liquid (often termed “mucus”) which overlies the surface epithelium of the airways. The liquid also contains electrolytes, immunoglobulins, plasma-derived proteins (for example albumin), lipids, enzymes, anti-enzymes, antibacterials, cell products and mediators. The relative contribution of each component to the normal functioning of the liquid is comparatively unknown, and the relevance of the liquid to airway homeostasis is, for the most part, only theoretical [1]. Mucins possess viscoelastic properties which confer upon the liquid the ability to be transported on the tips of beating cilia. Airborne particles are trapped in the liquid and are removed from the airways by mucociliary clearance. In disease, changes in the amount of liquid, or its viscoelasticity, or in the relative proportion of its components, convert a normally protective mechanism into a pathophysiological one. The altered mucus is difficult to clear and accumulates in the airways. The resulting airflow limitation contributes to morbidity and mortality in bronchial diseases such as asthma, chronic bronchitis and cystic fibrosis (CF)." @default.
- W89069999 created "2016-06-24" @default.
- W89069999 creator A5005714301 @default.
- W89069999 date "2001-01-01" @default.
- W89069999 modified "2023-09-25" @default.
- W89069999 title "Muscarinic control of airway mucus secretion" @default.
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- W89069999 doi "https://doi.org/10.1007/978-3-0348-8358-0_8" @default.
- W89069999 hasPublicationYear "2001" @default.
- W89069999 type Work @default.