Matches in SemOpenAlex for { <https://semopenalex.org/work/W89081103> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W89081103 abstract "The study of phytochemical constituents on the bark of Pseuduvaria Rugosa from the family Annonaceae has resulted in the isolation and characterization of aporphine alkaloids, benzo[7]annulene and tripenoids. Six aporphine alkaloids have been isolated from the dichloromethane and methanol crude extract of which three of them are new compounds. The known alkaloids were liriodenine 1, ouregidione 5, and Nmethylouregidione 11, whereas the new alkaloids were 3-amino-1,2-dimethoxy-4,5- dioxoaporphine (pseuduvarine A) 36, N-methyl-3-amino-1,2-dimethoxy-4,5- dioxoaporphine (pseuduvarine B) 37 and 3-hydroxy-1,2-dimethoxy-3,4-dioxoaporphine (pseuduvarine C) 38. The aporphine alkaloids with a substituted amino group at position C-3 in ring A have never been discovered in any plant species before. One compound with the benzo[7]annulene skeleton has been isolated from the methanol extract in very miniscule amount. The structural elucidation of this compound was done based on the mass spectroscopy spectrum and from the fragmentation pattern, this compound was identified as 1-hydroxy-2,3,9-trimethoxy-9-methyl-5H-benzo[7]annulene-5,6,7,8,(9H)- tetraone or Pseuduvarin 39. This compound is a novel compound and has never been isolated before. From the hexane extract, some of the compounds identified by GCMS were terpenoids and most of them were sesquiterpenes and diterpene including fatty acid esters. The major compounds found in the hexane extract were isoelemicin 40, 1,2,3,4-tetramethoxy- 5-(2-propenyl)benzene 41 and 3-hydroxy-1-propenyl-2- methoxyphenol 42. The other compounds are elemicin 24, spathulenol 29 and caryophyllene oxide 30. The sterol compounds found were stigmasterol 43 and gammasitosterol 44.This thesis also investigated the antioxidant and cytotoxic activities of the crude extracts and isolated compounds from Pseuduvaria Rugosa. The crude extracts and isolated compounds with sufficient quantities were tested for their radical scavenging activity using DPPH method and cytotoxic activity against selected cancer cell lines using the MTS and MTT assay. Preliminary bioactivity screening showed that the hexane, dichloromethane and methanol extracts of Pseuduvaria rugosa displayed weak to moderate activities in the radical scavenging activity but exhibited significant cytotoxic activities against seven cancer cell lines with more than 80% of cell death at 100 μg/ml. Ouregidione, N-methylouregidione and pseuduvarine C showed moderate cytotoxic activity on seven cancer cell lines. Pseuduvarine A and pseuduvarine B showed potent cytotoxicity against human cancer cell lines, MCF7 (IC50 : 0.9 μM, >50.0 μM), HepG2 (IC50: 21.7 μM, 15.7 μM) and HL-60 cells (IC50 : >50 μM, 12.4 μM)." @default.
- W89081103 created "2016-06-24" @default.
- W89081103 creator A5055671767 @default.
- W89081103 date "2011-01-01" @default.
- W89081103 modified "2023-09-23" @default.
- W89081103 title "Phytochemical and biological activity study on Pseuduvaria Rugosa (annonaceae) / Hairin Taha" @default.
- W89081103 hasPublicationYear "2011" @default.
- W89081103 type Work @default.
- W89081103 sameAs 89081103 @default.
- W89081103 citedByCount "0" @default.
- W89081103 crossrefType "dissertation" @default.
- W89081103 hasAuthorship W89081103A5055671767 @default.
- W89081103 hasConcept C178790620 @default.
- W89081103 hasConcept C185592680 @default.
- W89081103 hasConcept C195475562 @default.
- W89081103 hasConcept C2777667214 @default.
- W89081103 hasConcept C2778079118 @default.
- W89081103 hasConcept C2780303139 @default.
- W89081103 hasConcept C2780400988 @default.
- W89081103 hasConcept C2780471494 @default.
- W89081103 hasConcept C55493867 @default.
- W89081103 hasConcept C59822182 @default.
- W89081103 hasConcept C71240020 @default.
- W89081103 hasConcept C86803240 @default.
- W89081103 hasConceptScore W89081103C178790620 @default.
- W89081103 hasConceptScore W89081103C185592680 @default.
- W89081103 hasConceptScore W89081103C195475562 @default.
- W89081103 hasConceptScore W89081103C2777667214 @default.
- W89081103 hasConceptScore W89081103C2778079118 @default.
- W89081103 hasConceptScore W89081103C2780303139 @default.
- W89081103 hasConceptScore W89081103C2780400988 @default.
- W89081103 hasConceptScore W89081103C2780471494 @default.
- W89081103 hasConceptScore W89081103C55493867 @default.
- W89081103 hasConceptScore W89081103C59822182 @default.
- W89081103 hasConceptScore W89081103C71240020 @default.
- W89081103 hasConceptScore W89081103C86803240 @default.
- W89081103 hasLocation W890811031 @default.
- W89081103 hasOpenAccess W89081103 @default.
- W89081103 hasPrimaryLocation W890811031 @default.
- W89081103 hasRelatedWork W157710668 @default.
- W89081103 hasRelatedWork W158998195 @default.
- W89081103 hasRelatedWork W1995150731 @default.
- W89081103 hasRelatedWork W2008981647 @default.
- W89081103 hasRelatedWork W2029931208 @default.
- W89081103 hasRelatedWork W2030834701 @default.
- W89081103 hasRelatedWork W2081780343 @default.
- W89081103 hasRelatedWork W2338348553 @default.
- W89081103 hasRelatedWork W2368437346 @default.
- W89081103 hasRelatedWork W2425873596 @default.
- W89081103 hasRelatedWork W2577819845 @default.
- W89081103 hasRelatedWork W2588820608 @default.
- W89081103 hasRelatedWork W2901136893 @default.
- W89081103 hasRelatedWork W2903770366 @default.
- W89081103 hasRelatedWork W2912802700 @default.
- W89081103 hasRelatedWork W2985393451 @default.
- W89081103 hasRelatedWork W3024458799 @default.
- W89081103 hasRelatedWork W3162087740 @default.
- W89081103 hasRelatedWork W3196894147 @default.
- W89081103 hasRelatedWork W3082347924 @default.
- W89081103 isParatext "false" @default.
- W89081103 isRetracted "false" @default.
- W89081103 magId "89081103" @default.
- W89081103 workType "dissertation" @default.