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- W890830332 abstract "Proteolysis of both endogenous and exogenous substrates by the dialyzed soluble fraction of bovine corneal epithelium has been studied. Such variables as pH, temperature, and cation supplementation were chosen to simulate conditions as they may prevail during mechanical or thermal wounding. Endogenous proteolysis at physiologic pH and temperature is stimulated in decreasing order by Mn 2+ , Mg z+ , and Ca 2+ at optimal concentrations of 10 mM. At 50° C. the optimal concentrations of each cation is reduced to 2 mM. and Ca 2+ stimulation is markedly enhanced. The monovalent cations, and especially Na+, critically influence activity. Inhibition or activation of proteolysis by Na + appears to depend on the extent to which protein configurations are altered. The respective alkaline pH optima for unsupplemented and Mg z+ stimulated proteolysis at 37.5° C. is 8.0 and S.5. Soybean trypsin inhibitor has essentially no effect on proteolysis, and the Na + in sodium salicylate accounts for all but 7 per cent of the inhibition observable with this coynpound." @default.
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- W890830332 date "1967-08-01" @default.
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- W890830332 title "Proteolytic Activity of Bovine Corneal Epithelial Extracts" @default.
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