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- W89085384 abstract "Defensive responses to noxious stimulation are found throughout the animal kingdom, and nociceptors that detect incipient injury have been reported in species representing most of the major animal phyla. Emerging molecular genetic evidence indicates that at least some nociceptive transduction mechanisms have been widely conserved during evolution, notably mechanisms involving the degenerin/epithelial Na+ channel and transient receptor potential families of ion channels. Nociceptive neural networks show similarities across many species, including the use of inhibitory mechanisms to produce antinociception during active escape behavior. However, opiates and melanocortin receptors, as well as the mas-related genes family of receptors, may be restricted to the chordate lineage. Long-lasting, nociceptive sensitization often follows the antinociceptive phase after peripheral injury, and some mechanisms underlying this sensitization are conserved across phyla. Some of these are involved in plasticity of nociceptor synapses (N-methyl-d-asparate-receptor-dependent low-term synaptic potential) and regulation of gene transcription in nociceptive pathways (CREB activation). Knowledge gained from investigating homologous nociceptive mechanisms in various phyla can offer useful insights into how these mechanisms operate in humans. Comparative studies may also provide clues about the evolution of emotional aspects of pain, although subjective pain experiences in animals are not directly accessible for experimental investigation." @default.
- W89085384 created "2016-06-24" @default.
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- W89085384 date "2008-01-01" @default.
- W89085384 modified "2023-09-28" @default.
- W89085384 title "Evolutionary Aspects of Pain" @default.
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- W89085384 doi "https://doi.org/10.1016/b978-012370880-9.00155-9" @default.
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