Matches in SemOpenAlex for { <https://semopenalex.org/work/W89214632> ?p ?o ?g. }
Showing items 1 to 37 of
37
with 100 items per page.
- W89214632 abstract "Despite a century of often successful prevention and treatment efforts, infectious diseases remain an important global problem in public health, causing over 13 million deaths each year. This work has been developed on two areas of major concern nowadays: HIV-1 infection and emerging antimicrobial resistance.The first part of this thesis focused on the definition of the biological role of the dimerization of Nef, HIV-1 accessory protein. This function has been reported to take place in vivo, neveretheless it hasn’t been well characterized yet. We believe that the inihibition of Nef oligomerization may become an innovative and successful antiviral therapy. For this reason, we screened two different libraries of small molecules and peptides, to discover compounds hindering Nef-Nef interaction in vitro. The characterization of the viral protein aminoacidic residues taking part in the interaction with the compounds will provide precise indications about the dimerization surface. This region has not been identified unambiguously yet. Moreover, the administration of small molecules to HIV-1 infected cells will shed light on the effects of Nef dimerization inhibition on the viral life and infectious cycle.The second part of this work, aimed at determining the prevalence of fluoroquinolone resistance in Enterobacteriaceae samples, within our region. We focused our attention on the recently discovered plasmid-mediated mechanisms (PMQR). In the recent years, PMQR have spread rapidly all over the world, causing serious health concern, as they are often linked to both quinolone resistance and ESBL, giving rise to multi-resistant strains. Our study proved the large diffusion of these resistance determinants in the North East Italy. Furthermore, as the identification of new effective antimicrobial drugs is gaining more and more importance recently, we analysed the pharmacological activity and the mechanism of action of simocyclinone (SD8), a new antibiotic. SD8 has been demonstrated to have a broad spectrum of action, affecting both Gram positive and Gram negative bacterial species, so SD8 is likely to become a new antitopoisomerase drug." @default.
- W89214632 created "2016-06-24" @default.
- W89214632 creator A5084471843 @default.
- W89214632 date "2010-01-25" @default.
- W89214632 modified "2023-09-27" @default.
- W89214632 title "Nuove strategie antimicrobiche contro rilevanti patogeni umani" @default.
- W89214632 hasPublicationYear "2010" @default.
- W89214632 type Work @default.
- W89214632 sameAs 89214632 @default.
- W89214632 citedByCount "0" @default.
- W89214632 crossrefType "journal-article" @default.
- W89214632 hasAuthorship W89214632A5084471843 @default.
- W89214632 hasConcept C138816342 @default.
- W89214632 hasConcept C140704245 @default.
- W89214632 hasConcept C159047783 @default.
- W89214632 hasConcept C159110408 @default.
- W89214632 hasConcept C2522874641 @default.
- W89214632 hasConcept C25897203 @default.
- W89214632 hasConcept C3013748606 @default.
- W89214632 hasConcept C71924100 @default.
- W89214632 hasConcept C86803240 @default.
- W89214632 hasConceptScore W89214632C138816342 @default.
- W89214632 hasConceptScore W89214632C140704245 @default.
- W89214632 hasConceptScore W89214632C159047783 @default.
- W89214632 hasConceptScore W89214632C159110408 @default.
- W89214632 hasConceptScore W89214632C2522874641 @default.
- W89214632 hasConceptScore W89214632C25897203 @default.
- W89214632 hasConceptScore W89214632C3013748606 @default.
- W89214632 hasConceptScore W89214632C71924100 @default.
- W89214632 hasConceptScore W89214632C86803240 @default.
- W89214632 hasLocation W892146321 @default.
- W89214632 hasOpenAccess W89214632 @default.
- W89214632 hasPrimaryLocation W892146321 @default.
- W89214632 isParatext "false" @default.
- W89214632 isRetracted "false" @default.
- W89214632 magId "89214632" @default.
- W89214632 workType "article" @default.