Matches in SemOpenAlex for { <https://semopenalex.org/work/W892763313> ?p ?o ?g. }
Showing items 1 to 47 of
47
with 100 items per page.
- W892763313 abstract "This thesis describes the investigation into the development of novel antagonists of the major thrombin receptor, protease-activated receptor-1, in the aim of generating analogues of the project lead compound with improved metabolic stability. Chapter 1 provides an introduction to the research project and the biological rationale for targeting protease-activated receptor-1 for inhibition. Chapter 2 describes modifications made to the synthetic route to produce RWJ-58259, the project lead, and subsequent biological evaluation carried out in order to confirm the compound’s identity and verify batch quality. Chapter 3 describes the investigation into the metabolic profile of RWJ 58259 to identify major sites of metabolism. Presented in this chapter are details of the syntheses of analogues of RWJ-58259 incorporating substituents designed to block possible sites of metabolism in the aim of improving in vivo stability. The development of an in vitro assay suited to screen analogues efficiently is described and the results from the biological evaluation of compounds synthesised are presented with discussion of the data generated." @default.
- W892763313 created "2016-06-24" @default.
- W892763313 creator A5029571344 @default.
- W892763313 date "2015-03-28" @default.
- W892763313 modified "2023-09-28" @default.
- W892763313 title "Development of Novel Metabolically Stable Analogues of PAR-1 Antagonist RWJ-58259" @default.
- W892763313 cites W1530482317 @default.
- W892763313 hasPublicationYear "2015" @default.
- W892763313 type Work @default.
- W892763313 sameAs 892763313 @default.
- W892763313 citedByCount "0" @default.
- W892763313 crossrefType "dissertation" @default.
- W892763313 hasAuthorship W892763313A5029571344 @default.
- W892763313 hasConcept C181199279 @default.
- W892763313 hasConcept C185592680 @default.
- W892763313 hasConcept C202751555 @default.
- W892763313 hasConcept C21951064 @default.
- W892763313 hasConcept C2776714187 @default.
- W892763313 hasConcept C2777752112 @default.
- W892763313 hasConcept C2991874392 @default.
- W892763313 hasConcept C41008148 @default.
- W892763313 hasConcept C55493867 @default.
- W892763313 hasConcept C70721500 @default.
- W892763313 hasConcept C86803240 @default.
- W892763313 hasConceptScore W892763313C181199279 @default.
- W892763313 hasConceptScore W892763313C185592680 @default.
- W892763313 hasConceptScore W892763313C202751555 @default.
- W892763313 hasConceptScore W892763313C21951064 @default.
- W892763313 hasConceptScore W892763313C2776714187 @default.
- W892763313 hasConceptScore W892763313C2777752112 @default.
- W892763313 hasConceptScore W892763313C2991874392 @default.
- W892763313 hasConceptScore W892763313C41008148 @default.
- W892763313 hasConceptScore W892763313C55493867 @default.
- W892763313 hasConceptScore W892763313C70721500 @default.
- W892763313 hasConceptScore W892763313C86803240 @default.
- W892763313 hasLocation W8927633131 @default.
- W892763313 hasOpenAccess W892763313 @default.
- W892763313 hasPrimaryLocation W8927633131 @default.
- W892763313 hasRelatedWork W1507432491 @default.
- W892763313 hasRelatedWork W2085829368 @default.
- W892763313 hasRelatedWork W2280762929 @default.
- W892763313 hasRelatedWork W2285373015 @default.
- W892763313 hasRelatedWork W2884354480 @default.
- W892763313 isParatext "false" @default.
- W892763313 isRetracted "false" @default.
- W892763313 magId "892763313" @default.
- W892763313 workType "dissertation" @default.