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- W89302647 abstract "The liver has the broadest capability of any organ for biotransformation of xenobiotics. Consequently, it is the primary target for many toxins and thus, effects on it can be used as an index for potential long-term toxicity of xenobiotics. Two long-term biological effects of major concern are carcinogenicity and tumor enhancing activity. Hepatocarcinogens rapidly induce rodent liver altered foci characterized by a number of phenotypic abnormalities. Since evidence is available that such foci are precursors for liver neoplasms, the induction of foci can be used to detect carcinogens. Rat liver altered foci induced by limited exposures to carcinogens remain persistent or undergo phenotypic reversion following cessation of carcinogen exposure. In the presence of liver tumor promoters foci display enhanced persistance and progression. This effect can therefore be used to assess the tumor enhancing activity of xenobiotics." @default.
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- W89302647 date "1983-01-01" @default.
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- W89302647 title "LIMITED IN VIVO LIVER BIOASSAYS FOR IDENTIFYING LONG-TERM BIOLOGICAL EFFECTS" @default.
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- W89302647 doi "https://doi.org/10.1016/b978-0-08-029224-3.50083-6" @default.
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