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- W893211608 abstract "目的:寻找协同参与TM-TNF-α杀瘤作用的膜表面分子,探讨TM-TNF-α杀瘤及两型TNF-α生物学效应差异的分子机制。方法:利用抗体封闭实验及RT-PCR,检测ICAM-1及VCAM-1对TNFRI或TNFRII介导的TM-TNF-α杀瘤效应是否具有协同作用。结果:封闭表达TNFRI的MCF-7细胞表面的ICAM-1,可显著降低TM-TNF-α对其杀伤的作用;而封闭VCAM-1无明显效应。封闭表达TNFR II的HL-60细胞表面的ICAM-1或VCAM-1,均对TM-TNF-α的杀伤作用无影响。结论:ICAM-1对于TM-TNF-α通过I型受体介导的杀瘤效应具有协同作用。" @default.
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- W893211608 date "2004-01-01" @default.
- W893211608 modified "2023-09-24" @default.
- W893211608 title "ICAM-1协同参与TNFRI介导的TM-TNF-α杀瘤作用" @default.
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