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- W8932256 abstract "Green tea catechins ((−)-epicatechin ((−)-EC), (−)-epicatechin-3-gallate (ECG) (−)-epigallocatechin (EGC) and (−)-epigallocatechin-3-gallate (EGCG)) have shown the potential to reduce cardiovascular diseases and cancer, suppress inflammation, and inhibit viral or bacterial infections in recent in vitro cellular, animal and epidemiological studies. The pharmacokinetics and drug-drug interactions of catechins and their metabolites in humans will enable an understanding of their bioactivity and efficacy. ECG is not detected in human urine after green tea ingestion up to 664 mg. Gallated catechins (ECG and EGCG) in humans have longer T max and T 1/2 than non-gallated catechins (EC and EGC). Microbial metabolites in humans exhibit a longer T max compared to their parents. Catechins are involved in drug metabolism at the early stage and microbial metabolism at the later stage. After a single dose of green tea, EGCG had a plasma C max up to 5.6-fold higher in fasted humans than in fed humans. Studies have indicated that catechins are not inhibitors or inducers of CYP450 enzymes (1A2, 2C9, 2D6 and 3A4) in humans. Co-ingestion of green tea catechins with milk, bread, cheese or glucose by humans does not significantly modify their absorption, metabolism and excretion profiles." @default.
- W8932256 created "2016-06-24" @default.
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- W8932256 date "2013-01-01" @default.
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- W8932256 title "Drug Interactions with Green Tea Catechins in Humans" @default.
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- W8932256 doi "https://doi.org/10.1016/b978-0-12-384937-3.00082-3" @default.
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