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- W893284610 abstract "The notion that the conformation of ionic channels fluctuates in time is suggested by recent studies on the dynamics of proteins. Whereas long lived substates may be directly observed in records of single-channel currents, fast transitions may merely contribute to open-channel noise or may escape detection altogether. Such “hidden” substates nevertheless influence the measurable properties of channels such as the dependence of conductance on ion concentration. Because ions interact with the ligand system of the channel, transitions between different conformational substates will depend in general on whether a binding site is empty or occupied. If the rate of conformational transitions is comparable to the jumping rates of ions in the channel, coupling between conformational transitions and ion flow occurs. In this case, the permeability of the channel depends explicitly on the rate constants of conformational transitions. Many biological transport systems are likely to function by mechanisms intermediate between a “pure” carrier and a “pure” channel mechanism. The concept of a channel with multiple conformational substates may also be applied to ion pumps. A channel acts as a pump when the barrier structure of the channel is transiently modified by an external energy source in such a way that an ion binding site is switched from a left exposed to a right-exposed state." @default.
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- W893284610 date "1984-01-01" @default.
- W893284610 modified "2023-10-06" @default.
- W893284610 title "Channels with Multiple Conformational States: Interrelations with Carriers and Pumps" @default.
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- W893284610 doi "https://doi.org/10.1016/s0070-2161(08)60443-8" @default.
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