Matches in SemOpenAlex for { <https://semopenalex.org/work/W89356851> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W89356851 endingPage "24" @default.
- W89356851 startingPage "1916" @default.
- W89356851 abstract "Lens opacities developed within 48-72 hr in mice that received a series of eight injections of L-buthionine sulfoximine, a specific inhibitor of glutathione (GSH) biosynthesis, on postnatal days 8 and 9. Initial histopathologic features consisted of swollen fibers in the central anterior cortex and displacement of cell nuclei from the bow region to the posterior cortex. These aberrations suggest early fiber cell membrane and/or cytoskeletal dysfunction. A massive wave of fiber cell lysis then engulfed the entire lens cortex and nucleus within 24 hr and left only epithelial cells intact, suggesting a concerted mechanism of cataract generation. The acellular core of the mature cataract seen on postnatal day 16 consisted of a granular matrix in which pycnotic and fragmented cell nuclei were located near the terminus of the lens epithelium. The epithelium displayed increased mitotic activity and meridional row disorganization. During the next two weeks, rapid regeneration of lens fibers, displacement of the acellular necrotic cytoplasm to the center and rear of the lens, and vacuole formation were observed. As new fibers were differentiated, partial regeneration of the bow was seen. However, the cataract was irreversible." @default.
- W89356851 created "2016-06-24" @default.
- W89356851 creator A5002324639 @default.
- W89356851 creator A5011076158 @default.
- W89356851 creator A5015270985 @default.
- W89356851 creator A5039321169 @default.
- W89356851 creator A5069717524 @default.
- W89356851 creator A5079872185 @default.
- W89356851 creator A5086290297 @default.
- W89356851 date "1991-05-01" @default.
- W89356851 modified "2023-09-25" @default.
- W89356851 title "Rapid deterioration of lens fibers in GSH-depleted mouse pups." @default.
- W89356851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2032811" @default.
- W89356851 hasPublicationYear "1991" @default.
- W89356851 type Work @default.
- W89356851 sameAs 89356851 @default.
- W89356851 citedByCount "5" @default.
- W89356851 countsByYear W893568512022 @default.
- W89356851 countsByYear W893568512023 @default.
- W89356851 crossrefType "journal-article" @default.
- W89356851 hasAuthorship W89356851A5002324639 @default.
- W89356851 hasAuthorship W89356851A5011076158 @default.
- W89356851 hasAuthorship W89356851A5015270985 @default.
- W89356851 hasAuthorship W89356851A5039321169 @default.
- W89356851 hasAuthorship W89356851A5069717524 @default.
- W89356851 hasAuthorship W89356851A5079872185 @default.
- W89356851 hasAuthorship W89356851A5086290297 @default.
- W89356851 hasConcept C102568950 @default.
- W89356851 hasConcept C105702510 @default.
- W89356851 hasConcept C142724271 @default.
- W89356851 hasConcept C151730666 @default.
- W89356851 hasConcept C15336307 @default.
- W89356851 hasConcept C169760540 @default.
- W89356851 hasConcept C185592680 @default.
- W89356851 hasConcept C190062978 @default.
- W89356851 hasConcept C2777348757 @default.
- W89356851 hasConcept C2780723820 @default.
- W89356851 hasConcept C2909221355 @default.
- W89356851 hasConcept C529295009 @default.
- W89356851 hasConcept C71924100 @default.
- W89356851 hasConcept C86803240 @default.
- W89356851 hasConcept C95444343 @default.
- W89356851 hasConceptScore W89356851C102568950 @default.
- W89356851 hasConceptScore W89356851C105702510 @default.
- W89356851 hasConceptScore W89356851C142724271 @default.
- W89356851 hasConceptScore W89356851C151730666 @default.
- W89356851 hasConceptScore W89356851C15336307 @default.
- W89356851 hasConceptScore W89356851C169760540 @default.
- W89356851 hasConceptScore W89356851C185592680 @default.
- W89356851 hasConceptScore W89356851C190062978 @default.
- W89356851 hasConceptScore W89356851C2777348757 @default.
- W89356851 hasConceptScore W89356851C2780723820 @default.
- W89356851 hasConceptScore W89356851C2909221355 @default.
- W89356851 hasConceptScore W89356851C529295009 @default.
- W89356851 hasConceptScore W89356851C71924100 @default.
- W89356851 hasConceptScore W89356851C86803240 @default.
- W89356851 hasConceptScore W89356851C95444343 @default.
- W89356851 hasIssue "6" @default.
- W89356851 hasLocation W893568511 @default.
- W89356851 hasOpenAccess W89356851 @default.
- W89356851 hasPrimaryLocation W893568511 @default.
- W89356851 hasRelatedWork W1977294574 @default.
- W89356851 hasRelatedWork W1986953676 @default.
- W89356851 hasRelatedWork W2027659103 @default.
- W89356851 hasRelatedWork W2079116237 @default.
- W89356851 hasRelatedWork W2088056196 @default.
- W89356851 hasRelatedWork W2324371267 @default.
- W89356851 hasRelatedWork W2334882750 @default.
- W89356851 hasRelatedWork W2407335993 @default.
- W89356851 hasRelatedWork W3031427514 @default.
- W89356851 hasRelatedWork W3178209818 @default.
- W89356851 hasVolume "32" @default.
- W89356851 isParatext "false" @default.
- W89356851 isRetracted "false" @default.
- W89356851 magId "89356851" @default.
- W89356851 workType "article" @default.