Matches in SemOpenAlex for { <https://semopenalex.org/work/W89366188> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W89366188 endingPage "526" @default.
- W89366188 startingPage "525" @default.
- W89366188 abstract "Despite some confusion in the literature, drug-induced SLE is a well defined reversible clinical entity. The lupus syndromes induced by procainamide, hydralazine, and isoniazid have been well studied and the data obtained have been convincing. Other drugs may also induce a lupus syndrome, but adequate prospective studies have not been done. Furthermore, many other drugs previously incriminated appear to activate spontaneous SLE rather than induce the de novo lupus syndrome. The mechanism by which procainamide, hydralazine, and isoniazid exert their effect is not known, and animal studies have been unrewarding. However, hydralazine and procainamide are capable of complexing with nuclear antigens in vitro and possibly in vivo and may evoke antinuclear antibody responses in this way. A number of defined factors influence the development of the clinical syndrome, including the cumulative drug dosage, the acetylator phenotype of the individual, and the biochemical nature of the drug. Studies to date have not revealed how these drugs induce the clinical disease. While these agents may induce antinuclear antibodies in many individuals, genetic influences may be important in determining which patients will develop clinical symptoms. Further study of drug-induced systemic lupus erythematosus is necessary in order to resolve these problems regarding pathogenesis. The resolution of these problems may shed light on the pathogenesis of spontaneous SLE." @default.
- W89366188 created "2016-06-24" @default.
- W89366188 date "1969-04-21" @default.
- W89366188 modified "2023-09-24" @default.
- W89366188 title "Drug-induced systemic lupus erythematosus" @default.
- W89366188 doi "https://doi.org/10.1001/jama.208.3.525" @default.
- W89366188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6992215" @default.
- W89366188 hasPublicationYear "1969" @default.
- W89366188 type Work @default.
- W89366188 sameAs 89366188 @default.
- W89366188 citedByCount "37" @default.
- W89366188 countsByYear W893661882014 @default.
- W89366188 countsByYear W893661882016 @default.
- W89366188 crossrefType "journal-article" @default.
- W89366188 hasConcept C126322002 @default.
- W89366188 hasConcept C142724271 @default.
- W89366188 hasConcept C149443304 @default.
- W89366188 hasConcept C150903083 @default.
- W89366188 hasConcept C159654299 @default.
- W89366188 hasConcept C163764329 @default.
- W89366188 hasConcept C203014093 @default.
- W89366188 hasConcept C207001950 @default.
- W89366188 hasConcept C2775915377 @default.
- W89366188 hasConcept C2776912625 @default.
- W89366188 hasConcept C2776967927 @default.
- W89366188 hasConcept C2777028498 @default.
- W89366188 hasConcept C2779134260 @default.
- W89366188 hasConcept C2780035454 @default.
- W89366188 hasConcept C2780521442 @default.
- W89366188 hasConcept C2780942790 @default.
- W89366188 hasConcept C2781069245 @default.
- W89366188 hasConcept C71924100 @default.
- W89366188 hasConcept C84393581 @default.
- W89366188 hasConcept C86803240 @default.
- W89366188 hasConcept C98274493 @default.
- W89366188 hasConceptScore W89366188C126322002 @default.
- W89366188 hasConceptScore W89366188C142724271 @default.
- W89366188 hasConceptScore W89366188C149443304 @default.
- W89366188 hasConceptScore W89366188C150903083 @default.
- W89366188 hasConceptScore W89366188C159654299 @default.
- W89366188 hasConceptScore W89366188C163764329 @default.
- W89366188 hasConceptScore W89366188C203014093 @default.
- W89366188 hasConceptScore W89366188C207001950 @default.
- W89366188 hasConceptScore W89366188C2775915377 @default.
- W89366188 hasConceptScore W89366188C2776912625 @default.
- W89366188 hasConceptScore W89366188C2776967927 @default.
- W89366188 hasConceptScore W89366188C2777028498 @default.
- W89366188 hasConceptScore W89366188C2779134260 @default.
- W89366188 hasConceptScore W89366188C2780035454 @default.
- W89366188 hasConceptScore W89366188C2780521442 @default.
- W89366188 hasConceptScore W89366188C2780942790 @default.
- W89366188 hasConceptScore W89366188C2781069245 @default.
- W89366188 hasConceptScore W89366188C71924100 @default.
- W89366188 hasConceptScore W89366188C84393581 @default.
- W89366188 hasConceptScore W89366188C86803240 @default.
- W89366188 hasConceptScore W89366188C98274493 @default.
- W89366188 hasIssue "3" @default.
- W89366188 hasLocation W893661881 @default.
- W89366188 hasLocation W893661882 @default.
- W89366188 hasOpenAccess W89366188 @default.
- W89366188 hasPrimaryLocation W893661881 @default.
- W89366188 hasRelatedWork W120897673 @default.
- W89366188 hasRelatedWork W2000064261 @default.
- W89366188 hasRelatedWork W2010834428 @default.
- W89366188 hasRelatedWork W2014811916 @default.
- W89366188 hasRelatedWork W2049192283 @default.
- W89366188 hasRelatedWork W2089220991 @default.
- W89366188 hasRelatedWork W2412500734 @default.
- W89366188 hasRelatedWork W2415839216 @default.
- W89366188 hasRelatedWork W2993423240 @default.
- W89366188 hasRelatedWork W89366188 @default.
- W89366188 hasVolume "208" @default.
- W89366188 isParatext "false" @default.
- W89366188 isRetracted "false" @default.
- W89366188 magId "89366188" @default.
- W89366188 workType "article" @default.