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• W893882719 abstract "Sirolimus (SRL), a mammalian target of rapamycin inhibitor, has been used as a de novo base therapy with steroids and mycophenolate mofetil to avoid the use of calcineurin inhibitors. Our aim was to determine whether immunoregulation is promoted after conversion from tacrolimus (TAC) to SRL.The study included 24 renal transplant recipients who converted from TAC to SRL therapy and 24 normal controls. The frequency of T helper (Th) cells and the presence of signal transducer and activator of transcription (STAT) proteins in peripheral blood were analyzed by flow cytometry before conversion and at 3 and 6 months after conversion. Plasma levels of interleukin (IL)-1β, interferon-γ (IFN-γ), IL-17, IL-6, and IL-10 were analyzed by the Bio-Plex® suspension array system before and at 3 months after conversion.Renal transplant recipients who switched to SRL showed a significant increase in regulatory T cell (Treg) frequencies and better renal function compared with preconversion (P<0.05). The plasma concentrations of inflammatory cytokines IL-1β, IL-6, IL-17, and IFN-γ were significantly decreased after conversion to SRL. Furthermore, recipients who switched to SRL showed an increase in STAT5 activation and a decrease in STAT3 activation compared with the TAC group.Our results indicate that conversion to SRL might both minimize calcineurin inhibitor toxicity and promote immune tolerance." @default.
• W893882719 created "2016-06-24" @default.
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• W893882719 date "2015-09-01" @default.
• W893882719 modified "2023-10-17" @default.
• W893882719 title "Differential regulation of Tregs and Th17/Th1 cells by a sirolimus-based regimen might be dependent on STAT-signaling in renal transplant recipients" @default.
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• W893882719 doi "https://doi.org/10.1016/j.intimp.2015.07.006" @default.
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