Matches in SemOpenAlex for { <https://semopenalex.org/work/W89402261> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W89402261 abstract "Background and objectivesSalvia chloroleuca Rech. f. & Allen., is an endemic species growing wildly in north east and center parts of Iran but there is no information about its safety. To provide information about the safety of the species, we evaluated its acute and sub chronic toxicity in rats.MethodsIn acute toxicity study, the aqueous methanol (80%) extract at a single dose of 2000 mg/kg/day was administered orally to male and female rats and signs of toxicity two weeks after administration were observed. For the subchronic toxicity test, the extract at doses of 250, 500 and 1000 mg/kg/day were orally administered to the rats of both sexes for 45 days. Mortality, clinical signs of toxicity and body weight changes were monitored during the study. Moreover, α-amylase enzyme inhibition, total phenol content, and antioxidant (DPPH and FRAP assays) activity of different fractions of aerial part were evaluated.ResultsThe methanol and aqueous methanol (80%) extracts showed α-amylase enzyme inhibition with IC50 values 14.03 mg/mL and 18.05 mg/mL, respectively. The IC50 value for ethyl acetate, methanol and aqueous methanol (80%) extracts in radical scavenging assay were calculated as 288.83, 97.93, and 108.02 μg/mL, respectively. Among all extracts, methanol (228.4±12.05) demonstrated the highest FRAP value, followed by methanol (80%) extract (220.4±8.08) and ethyl acetate extract (156.4±10.06). In acute toxicity and subchronic study, neither mortality nor changes in behavior or any other parameter were observed.ConclusionOur findings indicate potent in vitro α-amylase and antioxidant activity of S. chloroleuca andpropose its potential as an anti-diabetic agent for treatment of noninsulin-dependent diabetes mellitus (NIDDM) patients." @default.
- W89402261 created "2016-06-24" @default.
- W89402261 creator A5029010665 @default.
- W89402261 creator A5055400538 @default.
- W89402261 creator A5063405597 @default.
- W89402261 creator A5068260359 @default.
- W89402261 creator A5075812920 @default.
- W89402261 date "2015-12-01" @default.
- W89402261 modified "2023-10-14" @default.
- W89402261 title "α-Amylase inhibitory property, antioxidant activity and toxicological study of Salvia chloroleuca" @default.
- W89402261 cites W1976086787 @default.
- W89402261 cites W1977476214 @default.
- W89402261 cites W2012644261 @default.
- W89402261 cites W2013837271 @default.
- W89402261 cites W2042962203 @default.
- W89402261 cites W2046968109 @default.
- W89402261 cites W2059684897 @default.
- W89402261 cites W2061839089 @default.
- W89402261 cites W2068877304 @default.
- W89402261 cites W2078811968 @default.
- W89402261 cites W2087856900 @default.
- W89402261 cites W2098548547 @default.
- W89402261 cites W2113523531 @default.
- W89402261 cites W2114004260 @default.
- W89402261 cites W2116962275 @default.
- W89402261 cites W2165292984 @default.
- W89402261 cites W2167543749 @default.
- W89402261 cites W2187334522 @default.
- W89402261 hasPublicationYear "2015" @default.
- W89402261 type Work @default.
- W89402261 sameAs 89402261 @default.
- W89402261 citedByCount "0" @default.
- W89402261 crossrefType "journal-article" @default.
- W89402261 hasAuthorship W89402261A5029010665 @default.
- W89402261 hasAuthorship W89402261A5055400538 @default.
- W89402261 hasAuthorship W89402261A5063405597 @default.
- W89402261 hasAuthorship W89402261A5068260359 @default.
- W89402261 hasAuthorship W89402261A5075812920 @default.
- W89402261 hasConcept C111472728 @default.
- W89402261 hasConcept C138885662 @default.
- W89402261 hasConcept C169760540 @default.
- W89402261 hasConcept C17077164 @default.
- W89402261 hasConcept C170835558 @default.
- W89402261 hasConcept C181199279 @default.
- W89402261 hasConcept C189950617 @default.
- W89402261 hasConcept C2776473397 @default.
- W89402261 hasConcept C2778004101 @default.
- W89402261 hasConcept C55493867 @default.
- W89402261 hasConcept C556039675 @default.
- W89402261 hasConcept C71924100 @default.
- W89402261 hasConcept C86803240 @default.
- W89402261 hasConceptScore W89402261C111472728 @default.
- W89402261 hasConceptScore W89402261C138885662 @default.
- W89402261 hasConceptScore W89402261C169760540 @default.
- W89402261 hasConceptScore W89402261C17077164 @default.
- W89402261 hasConceptScore W89402261C170835558 @default.
- W89402261 hasConceptScore W89402261C181199279 @default.
- W89402261 hasConceptScore W89402261C189950617 @default.
- W89402261 hasConceptScore W89402261C2776473397 @default.
- W89402261 hasConceptScore W89402261C2778004101 @default.
- W89402261 hasConceptScore W89402261C55493867 @default.
- W89402261 hasConceptScore W89402261C556039675 @default.
- W89402261 hasConceptScore W89402261C71924100 @default.
- W89402261 hasConceptScore W89402261C86803240 @default.
- W89402261 hasLocation W894022611 @default.
- W89402261 hasOpenAccess W89402261 @default.
- W89402261 hasPrimaryLocation W894022611 @default.
- W89402261 hasRelatedWork W2048095821 @default.
- W89402261 hasRelatedWork W2264718782 @default.
- W89402261 hasRelatedWork W2386501026 @default.
- W89402261 hasRelatedWork W2764841094 @default.
- W89402261 hasRelatedWork W2971563533 @default.
- W89402261 hasRelatedWork W3103071952 @default.
- W89402261 hasRelatedWork W3118096162 @default.
- W89402261 hasRelatedWork W4205654626 @default.
- W89402261 hasRelatedWork W4210433268 @default.
- W89402261 hasRelatedWork W4298229261 @default.
- W89402261 isParatext "false" @default.
- W89402261 isRetracted "false" @default.
- W89402261 magId "89402261" @default.
- W89402261 workType "article" @default.