FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W89414408> ?p ?o ?g. }

• W89414408 endingPage "189" @default.
• W89414408 startingPage "175" @default.
• W89414408 abstract "AbstractNormal developmental pathways that determine cell fate, migration, and proliferative potential become reactivated in cancer to promote the most devastating aspect of the disease, namely, metastasis to new sites. However, unlike their function in the delimited process of normal growth and differentiation, developmental pathways in the context of metastatic cancer support an aberrant and unlimited morphogenic program. Understanding how specific morphogenic pathways function in normal development and how they become deregulated in cancer may provide insight into new therapeutic opportunities to limit cancer spread. Adding complexity, however, such developmental pathways do not function solely through linear, cell autonomous programs but rather as dynamic, iterative processes between cells and their microenvironment. Therefore, comprehensive strategies to treat cancer and limit recurrence and metastasis must consider the ever-changing, reciprocal developmental relationship of cancer cells with their microenvironment. One important developmental pathway that shapes the interdependent evolution of breast cancer cells and their microenvironment is signaling by the embryonic morphogen Nodal, a member of the TGF-β family and a promising, new therapeutic target. Herein we review the significance of bidirectional signaling with the microenvironment in tumor progression and the distorted recapitulation of normal developmental programs that promote tumor aggression. Further, this chapter examines the reemergence of Nodal signaling during breast cancer growth and, finally, the therapeutic potential of targeting cancer cell–microenvironment interactions in general, and particularly Nodal signaling, to reprogram these relationships and promote a more benign developmental course in malignant breast cancer.KeywordsBreast CancerStem CellCancer Stem CellVasculogenic MimicryTumor Stem CellThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
• W89414408 created "2016-06-24" @default.
• W89414408 creator A5040563545 @default.
• W89414408 creator A5059592165 @default.
• W89414408 date "2013-01-01" @default.
• W89414408 modified "2023-09-24" @default.
• W89414408 title "Reprogramming Breast Cancer Cells with Embryonic Microenvironments: Insights from Nodal Signaling" @default.
• W89414408 cites W1600103888 @default.
• W89414408 cites W1645378787 @default.
• W89414408 cites W1908212812 @default.
• W89414408 cites W1965262464 @default.
• W89414408 cites W1966697925 @default.
• W89414408 cites W1967242562 @default.
• W89414408 cites W1968807484 @default.
• W89414408 cites W1975025595 @default.
• W89414408 cites W1988783376 @default.
• W89414408 cites W1990402395 @default.
• W89414408 cites W1992216512 @default.
• W89414408 cites W2001144553 @default.
• W89414408 cites W2007040134 @default.
• W89414408 cites W2009886857 @default.
• W89414408 cites W2013967591 @default.
• W89414408 cites W2014691022 @default.
• W89414408 cites W2017968214 @default.
• W89414408 cites W2023427658 @default.
• W89414408 cites W2034683528 @default.
• W89414408 cites W2035727526 @default.
• W89414408 cites W2037386012 @default.
• W89414408 cites W2042198997 @default.
• W89414408 cites W2054439316 @default.
• W89414408 cites W2062565240 @default.
• W89414408 cites W2064616338 @default.
• W89414408 cites W2065653828 @default.
• W89414408 cites W2070386387 @default.
• W89414408 cites W2071769253 @default.
• W89414408 cites W2077841029 @default.
• W89414408 cites W2086828029 @default.
• W89414408 cites W2103537491 @default.
• W89414408 cites W2104666893 @default.
• W89414408 cites W2112813549 @default.
• W89414408 cites W2118540634 @default.
• W89414408 cites W2131266938 @default.
• W89414408 cites W2136178883 @default.
• W89414408 cites W2137162822 @default.
• W89414408 cites W2138793636 @default.
• W89414408 cites W2141815918 @default.
• W89414408 cites W2146905485 @default.
• W89414408 cites W2147516356 @default.
• W89414408 cites W2149627453 @default.
• W89414408 cites W2152099298 @default.
• W89414408 cites W2152606216 @default.
• W89414408 cites W2153199196 @default.
• W89414408 cites W2153745983 @default.
• W89414408 cites W2157465258 @default.
• W89414408 cites W2493038526 @default.
• W89414408 cites W4211028684 @default.
• W89414408 doi "https://doi.org/10.1007/978-1-62703-634-4_9" @default.
• W89414408 hasPublicationYear "2013" @default.
• W89414408 type Work @default.
• W89414408 sameAs 89414408 @default.
• W89414408 citedByCount "0" @default.
• W89414408 crossrefType "book-chapter" @default.
• W89414408 hasAuthorship W89414408A5040563545 @default.
• W89414408 hasAuthorship W89414408A5059592165 @default.
• W89414408 hasConcept C104317684 @default.
• W89414408 hasConcept C121608353 @default.
• W89414408 hasConcept C129536746 @default.
• W89414408 hasConcept C145103041 @default.
• W89414408 hasConcept C1491633281 @default.
• W89414408 hasConcept C151730666 @default.
• W89414408 hasConcept C196843134 @default.
• W89414408 hasConcept C205583638 @default.
• W89414408 hasConcept C2776107976 @default.
• W89414408 hasConcept C2778386714 @default.
• W89414408 hasConcept C2779013556 @default.
• W89414408 hasConcept C2779343474 @default.
• W89414408 hasConcept C28328180 @default.
• W89414408 hasConcept C502942594 @default.
• W89414408 hasConcept C530470458 @default.
• W89414408 hasConcept C54355233 @default.
• W89414408 hasConcept C55427017 @default.
• W89414408 hasConcept C62478195 @default.
• W89414408 hasConcept C76419328 @default.
• W89414408 hasConcept C77255625 @default.
• W89414408 hasConcept C83330619 @default.
• W89414408 hasConcept C86803240 @default.
• W89414408 hasConcept C87073359 @default.
• W89414408 hasConcept C95444343 @default.
• W89414408 hasConcept C96232424 @default.
• W89414408 hasConceptScore W89414408C104317684 @default.
• W89414408 hasConceptScore W89414408C121608353 @default.
• W89414408 hasConceptScore W89414408C129536746 @default.
• W89414408 hasConceptScore W89414408C145103041 @default.
• W89414408 hasConceptScore W89414408C1491633281 @default.
• W89414408 hasConceptScore W89414408C151730666 @default.
• W89414408 hasConceptScore W89414408C196843134 @default.
• W89414408 hasConceptScore W89414408C205583638 @default.
• W89414408 hasConceptScore W89414408C2776107976 @default.

• next