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• W89477658 abstract "No AccessJournal of UrologyPediatric Articles1 Jul 1978Clinical and Endocrinological Evaluation of Patients with Congenital Microphallus Patrick C. Walsh, Jean D. Wilson, Terry D. Allen, James D. Madden, John C. Porter, William B. Neaves, James E. Griffin, and Willard E. Goodwin Patrick C. WalshPatrick C. Walsh More articles by this author , Jean D. WilsonJean D. Wilson More articles by this author , Terry D. AllenTerry D. Allen More articles by this author , James D. MaddenJames D. Madden More articles by this author , John C. PorterJohn C. Porter More articles by this author , William B. NeavesWilliam B. Neaves More articles by this author , James E. GriffinJames E. Griffin More articles by this author , and Willard E. GoodwinWillard E. Goodwin More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)57057-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Eight patients with congenital microphallus were investigated. Plasma luteinizing hormone, follicle-stimulating hormone, testosterone and androstenedione levels were obtained in all cases. In addition, the response to the administration of human chorionic gonadotropin, luteinizing hormone-releasing hormone and adrenocorticotropic hormone, the assessment of testicular histology by electron microscopy and the measurement of dihydrotestosterone formation by preputial skin were determined in some patients. The results of these studies were compared to similar studies in 6 normal prepubertal boys, 4 boys with bilateral cryptorchidism, 1 male infant with anorchia and 1 adult with hypogonadotropic hypogonadism. The clinical and endocrinological findings in the 8 patients with microphallus can be divided into 2 distinct categories. In 5 patients the disorder is familial, gonadotropin levels are low and there is a normal response to stimulation with chorionic gonadotropin. The data are compatible with the possibility that 3 (possibly 5) of the 8 patients with microphallus have hypogonadotropic hypogonadism. In the other group the cases are sporadic, serum luteinizing hormone and folliclestimulating hormone levels are elevated and plasma testosterone failed to increase after shortterm treatment with chorionic gonadotropin. In these patients a primary testicular disorder appears to be responsible. Experimental and clinical evidence suggests that microphallus results from defective testicular function during the second and third trimesters of pregnancy, either as the result of defective gonadotropin secretion or defective androgen synthesis. © 1978 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByTIETJEN D, URAMOTO G, TINDALL D and HUSMANN D (2018) MICROPENIS IN HYPOGONADOTROPIC HYPOGONADISM: RESPONSE OF THE PENILE ANDROGEN RECEPTOR TO TESTOSTERONE TREATMENTJournal of Urology, VOL. 160, NO. 3 Part 2, (1054-1057), Online publication date: 1-Sep-1998.McMahon D, Kramer S and Husmann D (2018) Micropenis: Does Early Treatment with Testosterone Do More Harm Than Good?Journal of Urology, VOL. 154, NO. 2, (825-829), Online publication date: 1-Aug-1995.Husmann D and Cain M (2018) Microphallus: Eventual Phallic Size is Dependent on the Timing of Androgen AdministrationJournal of Urology, VOL. 152, NO. 2 Part 2, (734-739), Online publication date: 1-Aug-1994.Nonomura K, Sakakibara N, Demura T, Mori T and Koyanagi T (2018) Androgen Binding Activity in the Spongy Tissue of Mammalian PenisJournal of Urology, VOL. 144, NO. 1, (152-155), Online publication date: 1-Jul-1990.Jarow J, Berkovitz G, Migeon C, Gearhart J and Walsh P (2018) Elevation of Serum Gonadotropins Establishes the Diagnosis of Anorchism in Prepubertal Boys with Bilateral CryptorchidismJournal of Urology, VOL. 136, NO. 1 Part 2, (277-279), Online publication date: 1-Jul-1986.Elder J (2018) Re: Pitfalls in Using Human Chorionic Gonadotropin Stimulation Test to Diagnose Anorchia, by F. F. Bartone, C. A. Huseman, M. Maizels and C. F. Firlit, J. Urol., 132: 563–567, 1984Journal of Urology, VOL. 133, NO. 4, (690-690), Online publication date: 1-Apr-1985.Hinman F (2018) Microphallus: Distinction Between Anomalous and Endocrine TypesJournal of Urology, VOL. 123, NO. 3, (412-415), Online publication date: 1-Mar-1980.P.C.W. (2018) Editorial CommentJournal of Urology, VOL. 123, NO. 3, (415-415), Online publication date: 1-Mar-1980. (2018) Reply by AuthorJournal of Urology, VOL. 123, NO. 3, (415-415), Online publication date: 1-Mar-1980. Volume 120Issue 1July 1978Page: 90-95 Advertisement Copyright & Permissions© 1978 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Patrick C. Walsh More articles by this author Jean D. Wilson More articles by this author Terry D. Allen More articles by this author James D. Madden More articles by this author John C. Porter More articles by this author William B. Neaves More articles by this author James E. Griffin More articles by this author Willard E. Goodwin More articles by this author Expand All Advertisement Loading ..." @default.
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• W89477658 title "Clinical and Endocrinological Evaluation of Patients with Congenital Microphallus" @default.
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